Evidence map›Paper›PMID 30546465›Full record

ArticleOncology letters2018

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.

Yuta Sato, Shin-Ei Kudo, Katsuro Ichimasa, Shingo Matsudaira, Yuta Kouyama, Kazuki Kato, Toshiyuki Baba, Kunihiko Wakamura, Takemasa Hayashi, Toyoki Kudo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yuta SatoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Shin-Ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Katsuro IchimasaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Shingo MatsudairaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Yuta KouyamaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Kazuki KatoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Toshiyuki BabaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Kunihiko WakamuraDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Takemasa HayashiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Toyoki KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Noriyuki OgataDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Yuichi MoriDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Masashi MisawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Naoya ToyoshimaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Tomoyuki IshigakiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Yusuke YagawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Hiroki NakamuraDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Tatsuya SakuraiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Yukiko ShakuoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Kenichi SuzukiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Yui KudoEndoscopic Division, Kudo Clinic, Akita 010-0001, Japan.
Shigeharu HamataniDepartment of Pathology, Jikei University School of Medicine, Tokyo 105-8471, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
Hideyuki MiyachiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. A total of 741 patients with T1 CRCs that were resected surgically between April 2001 and October 2016 in our hospital were divided into two groups: With SLVI and without SLVI. Clinicopathological features compared between the two groups were patient's gender, age, tumor size, location, morphology, lymphovascular invasion, tumor differentiation, tumor budding and lymph node metastasis. The incidence of T1 CRCs with SLVI was 0.9% (7/741). All cases with SLVI were found in the sigmoid colon or rectum. T1 CRCs with SLVI showed significantly higher rates of lymphovascular invasion than those without SLVI (P<0.01). In conclusion, lymphovascular invasion was a significant risk factor for SLVI in T1 CRCs, and for which surgical colectomy was necessary. The Japanese guidelines are appropriate regarding SLVI. Registered in the University Hospital Medical Network Clinical Trials Registry (UMIN000027097).

Indexed as

colorectal carcinomaendoscopic resectionlymphovascular invasionskip metastasisT1 carcinoma

Identifiers

PMID30546465
PMCPMC6256327

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.