Evidence map›Paper›PMID 30546139›Full record

ArticleNature2018

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Silvia A Purro, Mark A Farrow, Jacqueline Linehan, Tamsin Nazari, David X Thomas, Zhicheng Chen, David Mengel, Takashi Saito, Takaomi Saido, Peter Rudge and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. TDP-43 Aggregation: The Healthy-Toxic Balance of the Prion-Like Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Strain-specific propagation of variant Creutzfeldt-Jakob disease prions in humanized neural cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
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  11. Article
  12. Article
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  16. Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Silvia A PurroMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Mark A FarrowMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Jacqueline LinehanMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Tamsin NazariMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
David X ThomasMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Zhicheng ChenLaboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
David MengelLaboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Japan.
Takaomi SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Japan.
Peter RudgeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Sebastian BrandnerMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Dominic M WalshMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK. jc@prion.ucl.ac.uk.
University College London · GBHarvard University · USMRC Prion Unit · GBRIKEN Center for Brain Science · JP

Funding

Water-soluble Abeta and its role in Alzheimer's diseaseR01AG046275 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SELKOE, DENNIS J · 2014 to 2018
$1.8M
Medical Research Council G1000691Medical Research Council MC_UP_1604/1Medical Research Council MR/L022656/1NIA NIH HHS R01 AG046275
6 · The paper itself

Abstract

We previously reported

Indexed as

CadaverDrug ContaminationIatrogenic DiseaseAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsCase-Control StudiesCreutzfeldt-Jakob SyndromeDisease Models, AnimalDisease Transmission, InfectiousFemaleGrowth HormoneHumansMaleMiceAmyloid beta-PeptidesAmyloid beta-Protein PrecursorGrowth HormonePrionsRecombinant Proteinstau Proteins

Identifiers

PMID30546139
PMCPMC6708408
OpenAlexW2905542822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.