ArticleNature microbiology2019
Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
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- Bacterial and host factors affecting acquisition ofbioRxiv : the preprint server for biology · 2026Article
- Colonization dynamics ofInfection and immunity · 2025Article
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- A strong priority effect in the assembly of a specialized insect-microbe symbiosis.Applied and environmental microbiology · 2024Article
- Ecological drift during colonization drives within-host and between-host heterogeneity in an animal-associated symbiont.PLoS biology · 2024Article
- Time-resolved RNA-seq analysis to unravel theMicrobiology spectrum · 2024Article
- Variation in pneumococcal invasiveness metrics is driven by serotype carriage duration and initial risk of disease.Epidemics · 2023Article
- Structural basis of peptide secretion for Quorum sensing by ComA.Nature communications · 2023Article
- Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions.PLoS pathogens · 2023Article
- BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection.Cell host & microbe · 2023Article
- Antagonism of volatile organic compounds of the Bacillus sp. against Fusarium kalimantanense.World journal of microbiology & biotechnology · 2022Article
- Epidemiological dynamics of bacteriocin competition and antibiotic resistance.Proceedings. Biological sciences · 2022Article
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5 authors at 2 institutions in 1 country.
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Abstract
Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumoniae use owner-intruder asymmetries to settle contests, leading to the disproportionate success of the initial resident 'owner', regardless of the genetic identity of the 'intruder'. We investigated the determinants of within-host competitive success utilizing S. pneumoniae colonization of the upper respiratory tract of infant mice. Within 6 h, colonization by the resident inhibited colonization by an isogenic challenger. The competitive advantage of the resident was dependent on quorum sensing via the competence (Com) regulon and downstream choline binding protein D (CbpD) and on the competence-induced bacteriocins A and B (CibAB) implicated in fratricide. CbpD and CibAB are highly conserved across pneumococcal lineages, indicating evolutionary advantages for asymmetric competitive strategies within the species. Mathematical modelling supported a significant role for quorum sensing via the Com regulon in competition, even for strains with different competitive advantages. Our study suggests that asymmetric owner-intruder competitive strategies do not require complex cognition and are used by a major human pathogen to determine 'ownership' of human hosts.
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