Evidence map›Paper›PMID 30546068›Full record

ArticleBone marrow transplantation2019

A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia-lymphoma.

Makoto Yoshimitsu, Atae Utsunomiya, Shigeo Fuji, Hiroshi Fujiwara, Takahiro Fukuda, Hiroyasu Ogawa, Yoshifusa Takatsuka, Kenji Ishitsuka, Akira Yokota, Hirokazu Okumura and 10 more

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

Makoto YoshimitsuDepartment of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan. myoshimi@m.kufm.kagoshima-u.ac.jp.
Atae UtsunomiyaDepartment of Hematology, Imamura General Hospital, Kagoshima, Japan.
Shigeo FujiDepartment of Hematology, Osaka International Cancer Center, Osaka, Japan.ORCID 0000-0001-5118-7950
Hiroshi FujiwaraDepartment of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University, Ehime, Japan.
Takahiro FukudaDepartment of Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Hiroyasu OgawaDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Yoshifusa TakatsukaDepartment of Hematology, Imamura General Hospital, Kagoshima, Japan.
Kenji IshitsukaDepartment of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan.
Akira YokotaDepartment of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan.
Hirokazu OkumuraDepartment of Internal Medicine (Hematology), Toyama Prefectural Central Hospital, Toyama, Japan.
Kazuyoshi IshiiDepartment of Hematology and Oncology, Kansai Medical University Medical Center, Osaka, Japan.
Akinori NishikawaDepartment of Hematology, Wakayama Medical University, Wakayama, Japan.
Tetsuya EtoDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Akihito YonezawaDepartment of Hematology, Kokura Memorial Hospital, Fukuoka, Japan.
Kaname MiyashitaDepartment of Hematology, National Kyushu Cancer Center, Fukuoka, Japan.
Junichi TsukadaDepartment of Hematology, University of Occupational and Environmental Health, Fukuoka, Japan.
Junji TanakaDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Aichi, Japan.
Koji KatoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation
Kagoshima University Hospital · JPHyogo Medical University · JPKansai Medical University · JPKyushu University · JPUniversity of Occupational and Environmental Health Japan · JPEhime University · JPHamanomachi Hospital · JPImamura Hospital · JPNational Hospital Organization Kyushu Cancer Center · JPOsaka International Cancer Institute · JPTokyo Women's Medical University · JPToyama Prefectural Central Hospital · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only available curative modality for patients with adult T-cell leukemia-lymphoma (ATL). When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sources, especially cord blood and conventional HLA haplo-identical donors, are needed to validate the safety and efficacy of this modality. In this study, we retrospectively evaluated the outcome of allo-HCT without PTCY in patients with ATL registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database between 1985 and 2015. During that period, 46 patients received allo-HCT without PTCY and survivors were followed for a median of 2316.5 days (range: 220-3884 days). Although the estimated 1- and 5-year overall survival rates of the entire cohort were 34.5% and 17.7%, respectively, the cumulative 1- and 5-year non-ATL mortality rates of 41.3% and 55.8%, respectively, were high. The results of our study will serve as a platform for discussions of the safety and efficacy of haplo-HCT for future clinical trials in patients with ATL.

Indexed as

FemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility TestingHumansLeukemia-Lymphoma, Adult T-CellMaleRetrospective StudiesTransplantation Conditioning

Identifiers

PMID30546068
OpenAlexW2905525907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.