Evidence map›Paper›PMID 30546048›Full record

ArticleNature communications2018

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.

Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel Asfaha, Kelly S Patterson, Ashok Singh, Xiangdong Yang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Heuijoon ParkDepartment of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.
Sonali LadThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Kelsey BolandThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Kelly JohnsonThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Nyssa ReadioThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Guangchun JinDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
Samuel AsfahaDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
Kelly S PattersonDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
Ashok SinghThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Xiangdong YangDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
Douglas LondonoDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854-8082, NJ, USA.
Anupama SinghThe Hormel Institute, University of Minnesota, Austin, 55912, MN, USA.
Carol TrempusMatrix Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, 27709, NC, USA.
Derek GordonDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854-8082, NJ, USA.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, 10032, NY, USA.
Rebecca J MorrisDepartment of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA. rmorris@hi.umn.edu.
Columbia University · USHormel (United States) · USUniversity of Minnesota · USRutgers, The State University of New Jersey · USNational Institute of Environmental Health Sciences · US

Funding

Cancer and Cell Lineages From Hair Follicle Stem CellsR01CA097957 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORRIS, REBECCA JANE · 2002 to 2007
$2.1M
The regulation of keratinocyte stem cellsR01AR052713 · NIAMS · UNIVERSITY OF MINNESOTA · PI MORRIS, REBECCA JANE · 2006 to 2010
$1.7M
The Role of Bone Marrow Derived Cells in Skin CancerR21CA124942 · NCI · UNIVERSITY OF MINNESOTA · PI MORRIS, REBECCA JANE · 2010 to 2011
$356k
NCI NIH HHS R01 CA097957NCI NIH HHS R21 CA124942NIAMS NIH HHS R01 AR052713
6 · The paper itself

Abstract

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Lineage-depleted BMCs migrated towards High Mobility Group Box 1 (HMGB1) protein and epidermal KCs in ex vivo invasion assays. Naive female mice receiving BMTs from DMBA-treated donors developed benign and malignant lesions after TPA promotion alone. We conclude that BMDECs contribute to the development of papillomas and dysplasia, demonstrating a systemic contribution to these lesions. Furthermore, carcinogen-exposed BMCs can initiate benign and malignant lesions upon tumor promotion. Ultimately, these findings may suggest targets for treatment of non-melanoma skin cancers.

Indexed as

9,10-Dimethyl-1,2-benzanthraceneAnimalsBone Marrow CellsBone Marrow TransplantationBone Morphogenetic Protein 5Cell MovementCell PlasticityCell Transformation, NeoplasticCoculture TechniquesEpithelial CellsFemaleHair FollicleHMGB1 ProteinKeratinocytesKeratinsMale9,10-Dimethyl-1,2-benzanthraceneBmp5 protein, mouseBone Morphogenetic Protein 5HMGB1 ProteinHMGB1 protein, mouseKeratinsTetradecanoylphorbol Acetate

Identifiers

PMID30546048
PMCPMC6294255
OpenAlexW2904844856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.