ArticleTranslational psychiatry2018
Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Affective cognition in eating disorders: a systematic review and meta-analysis of the performance on the "Reading the Mind in the Eyes" Test.Eating and weight disorders : EWD · 2022Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Structural and functional brain alterations in anorexia nervosa:A multimodal meta-analysis of neuroimaging studies.Human brain mapping · 2021Pooled it
- Regional gray matter alterations in anorexia nervosa: implications for subtype heterogeneity and clinical severity.Molecular psychiatry · 2026Article
- Chronic activity-based anorexia triggers a glial response in the hippocampus independent of intestinal epithelial toll-like receptor 4.Journal of neuroinflammation · 2026Article
- The Relationship Between Precuneus Thickness and Psychopathology in Adolescent Females With Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Neurobiology and Cognition in Girls at High-Risk of Eating Disorders: Exploring Imaging-Derived Trait Markers.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Body Mass Index Impacts on Gray Matter Volume in Developmental Restrictive Anorexia Nervosa: A Voxel-Based Morphometry Study.Nutrients · 2025Article
- Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology.Biological psychiatry · 2025Article
- The Impact of Age on Gray Matter Volume Reduction in Anorexia Nervosa: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Mapping gray matter changes in anorexia nervosa: a functional connectivity network approach.Frontiers in nutrition · 2025Article
- Transient patterns of advanced brain ageing in female adolescents with anorexia nervosa.The British journal of psychiatry : the journal of mental science · 2024Article
- Causal Relationship between Aging and Anorexia Nervosa: A White-Matter-Microstructure-Mediated Mendelian Randomization Analysis.Biomedicines · 2024Article
- Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study.Molecular psychiatry · 2024Article
- Lower region-specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa.The International journal of eating disorders · 2024Article
- Serum neurofilament light concentrations are associated with cortical thinning in anorexia nervosa.Psychological medicine · 2023Article
- Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels.Psychological medicine · 2023Article
- Association of body mass index and its classifications with gray matter volume in individuals with a wide range of body mass index group: A whole-brain magnetic resonance imaging study.Frontiers in human neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality. The underlying neurobiological mechanisms are not well understood, and high-resolution structural magnetic resonance brain imaging studies have given inconsistent results. Here we aimed to psychoradiologically define the most prominent and replicable abnormalities of gray matter volume (GMV) in AN patients, and to examine their relationship to demographics and clinical characteristics, by means of a new coordinate-based meta-analytic technique called seed-based d mapping (SDM). In a pooled analysis of all AN patients we identified decreased GMV in the bilateral median cingulate cortices and posterior cingulate cortices extending to the bilateral precuneus, and the supplementary motor area. In subgroup analysis we found an additional decreased GMV in the right fusiform in adult AN, and a decreased GMV in the left amygdala and left anterior cingulate cortex in AN patients without comorbidity (pure AN). Thus, the most consistent GMV alterations in AN patients are in the default mode network and the sensorimotor network. These psychoradiological findings of the brain abnormalities might underpin the neuropathophysiology in AN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.