Evidence map›Paper›PMID 30546040›Full record

ArticleScientific reports2018

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

Zoe V Schofield, Daniel Croker, Avril A B Robertson, Nicholas L Massey, Chantal Donovan, Ernest Tee, David Edwards, Trent M Woodruff, Reena Halai, Philip M Hansbro and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zoe V SchofieldInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Daniel CrokerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Avril A B RobertsonThe School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0002-9652-8357
Nicholas L MasseyInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Chantal DonovanPriority Centre for Healthy Lungs, University of Newcastle & Hunter Medical Research Institute, Newcastle, NSW, Australia.
Ernest TeeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
David EdwardsInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Trent M WoodruffSchool of Biomedical Sciences, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0003-1382-911X
Reena HalaiInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Philip M HansbroPriority Centre for Healthy Lungs, University of Newcastle & Hunter Medical Research Institute, Newcastle, NSW, Australia.
Matthew A CooperInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. M.cooper@uq.edu.au.ORCID http://orcid.org/0000-0003-3147-3460
The University of Queensland · AUHunter Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) and 4-((4-(2-chlorophenyl)thiazole-2-yl)amino)-4oxo-3-phenylbutanoic acid (2CTAP), and their enantiomers, in modulating FFA2 activity. The racemic mixture (R/S) and its constituents (R-) and (S-) 4CMTB or 2CTAP were used to stimulate human (h)FFA2 in the absence or presence of acetate. Calcium ions (Ca

Indexed as

Fatty Acids, VolatileReceptors, Cell SurfaceAnimalsCHO CellsCricetulusCyclic AMPHumansLigandsMAP Kinase Signaling SystemMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors, G-Protein-CoupledSecond Messenger SystemsCyclic AMPFatty Acids, VolatileFFAR2 protein, humanLigandsMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors, Cell SurfaceReceptors, G-Protein-Coupled

Identifiers

PMID30546040
PMCPMC6292860
OpenAlexW2904606153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.