ArticleNature communications2018
Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Predicting the geographical distribution of drug use disorder in Sweden from the geographical variation in social deprivation, genetic risk and urbanization.Molecular psychiatry · 2026Article
- Schizophrenia.Nature reviews. Disease primers · 2025Review
- The geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.Psychological medicine · 2024Article
- Geospatial investigations in Colombia reveal variations in the distribution of mood and psychotic disorders.Communications medicine · 2024Article
- Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity.Social psychiatry and psychiatric epidemiology · 2024Article
- Social Deprivation and Population Density Trajectories Before and After Psychotic Disorder Diagnosis.JAMA psychiatry · 2023Article
- Heritability Estimation of Cognitive Phenotypes in the ABCD StudyBehavior genetics · 2023Article
- The Incidence of Psychotic Disorders and Area-level Marginalization in Ontario, Canada: A Population-based Retrospective Cohort Study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- Urban-Rural Differences in Schizophrenia Risk: Multilevel Survival Analyses of Individual- and Neighborhood-Level Indicators, Urbanicity and Population Density in a Danish National Cohort Study.Schizophrenia bulletin open · 2022Article
- Environmental Risk Factors and Psychotic-like Experiences in Children Aged 9-10.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study.Journal of molecular neuroscience : MN · 2020Article
- Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia.JAMA network open · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Spatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028), drawn from the 1.47 million Danish persons born between 1981 and 2005, using a novel framework for decomposing the geospatial risk for schizophrenia based on locale of upbringing and polygenic scores. Upbringing in a high environmental risk locale increases the risk for schizophrenia by 122%. Individuals living in a high gene-by-environmental risk locale have a 78% increased risk compared to those who have the same genetic liability but live in a low-risk locale. Effects of specific locales vary substantially within the most densely populated city of Denmark, with hazard ratios ranging from 0.26 to 9.26 for environment and from 0.20 to 5.95 for gene-by-environment. These findings indicate the critical synergism of gene and environment on the etiology of schizophrenia and demonstrate the potential of incorporating geolocation in genetic studies.
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