Evidence map›Paper›PMID 30545965›Full record

ArticleScience translational medicine2018

The

Qingtuan Meng, Kangli Wang, Tonya Brunetti, Yan Xia, Chuan Jiao, Rujia Dai, Dominic Fitzgerald, Amber Thomas, Lindsey Jay, Heather Eckart and 7 more

Abstract read
In one paragraph

Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Psychiatric Genomics 2025: State of the Art and the Path Forward.The Psychiatric clinics of North America · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Focus on your locus with a massively parallel reporter assay.Journal of neurodevelopmental disorders · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qingtuan MengCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0002-6421-162X
Kangli WangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Tonya BrunettiInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
Yan XiaCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0001-6432-9911
Chuan JiaoCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Rujia DaiCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0002-9979-3295
Dominic FitzgeraldInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9045-4043
Amber ThomasInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7346-3052
Lindsey JayInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4465-7795
Heather EckartInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9332-3073
Kay GrennanDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.
Yuka Imamura-KawasawaDepartments of Pharmacology and Biochemistry and Molecular Biology, Institute for Personalized Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-8638-6738
Mingfeng LiDepartment of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7959-6008
Nenad SestanDepartment of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0966-9619
Kevin P WhiteInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6934-5793
Chao ChenCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. chenchao@sklmg.edu.cn liuch@upstate.edu.ORCID 0000-0002-5114-2282
Chunyu LiuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. chenchao@sklmg.edu.cn liuch@upstate.edu.ORCID 0000-0002-5986-4415

Funding

Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9M
Cis-Regulatory Epigenome Mappings in SchizophreniaU01MH103392 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, SKLAR, PAMELA · 2014 to 2017
$7.6M
Molecular Profiling of SchizophreniaR01MH110921 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHESS, ANDREW J, ROUSSOS, PANAGIOTIS · 2016 to 2020
$6.9M
Transcriptional and Epigenetic Signatures of Human Brain Development and AutismU01MH103339 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD, STATE, MATTHEW W. · 2014 to 2017
$6.5M
Risk genetic variants and cis regulation of gene expression in Bipolar DisorderR01MH109677 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2016 to 2020
$4.6M
Genetic variants affect brain gene expression and risks of psychiatric disordersU01MH103340 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU, RZHETSKY, ANDREY · 2014 to 2017
$4.3M
Integrative Genomics of the Corticolimbic Circuit in Major Depressive DisorderR01MH111721 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GOES, FERNANDO SAMPAIO, HYDE, THOMAS MICHAEL · 2017 to 2021
$4.2M
Mapping the role of long noncoding RNAs in gene regulatory networks in schizophreniaR01MH109715 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PINTO, DALILA · 2018 to 2022
$4.0M
1/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110926 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2016 to 2019
$3.2M
RNA Sequencing of the Limbic System in Bipolar DisorderR01MH105898 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HYDE, THOMAS MICHAEL, ZANDI, PETER P. · 2015 to 2018
$3.1M
Epigenetic and Transcriptional Dysregulation in Autism Spectrum DisorderR01MH094714 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2011 to 2015
$2.8M
2/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110927 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2016 to 2019
$2.7M
NIEHS NIH HHS R01 ES024988NIMH NIH HHS P50 MH106934NIMH NIH HHS R01 MH080425NIMH NIH HHS R01 MH094714NIMH NIH HHS R01 MH105898NIMH NIH HHS R01 MH109677NIMH NIH HHS R01 MH109715NIMH NIH HHS R01 MH110905NIMH NIH HHS R01 MH110920NIMH NIH HHS R01 MH110921NIMH NIH HHS R01 MH110926NIMH NIH HHS R01 MH110927NIMH NIH HHS R01 MH110928NIMH NIH HHS R01 MH111721NIMH NIH HHS R21 MH102791NIMH NIH HHS R21 MH103877NIMH NIH HHS R21 MH105853NIMH NIH HHS R21 MH105881NIMH NIH HHS R21 MH109956NIMH NIH HHS U01 MH103339NIMH NIH HHS U01 MH103340NIMH NIH HHS U01 MH103346NIMH NIH HHS U01 MH103365NIMH NIH HHS U01 MH103392
6 · The paper itself

Abstract

A number of studies indicate that rare copy number variations (CNVs) contribute to the risk of schizophrenia (SCZ). Most of these studies have focused on protein-coding genes residing in the CNVs. Here, we investigated long noncoding RNAs (lncRNAs) within 10 SCZ risk-associated CNV deletion regions (CNV-lncRNAs) and examined their potential contribution to SCZ risk. We used RNA sequencing transcriptome data derived from postmortem brain tissue from control individuals without psychiatric disease as part of the PsychENCODE BrainGVEX and Developmental Capstone projects. We carried out weighted gene coexpression network analysis to identify protein-coding genes coexpressed with CNV-lncRNAs in the human brain. We identified one neuronal function-related coexpression module shared by both datasets. This module contained a lncRNA called

Indexed as

Gene Expression RegulationAdultBrainDNA Copy Number VariationsHumansMolecular Sequence AnnotationOpen Reading FramesRisk FactorsRNA, Long NoncodingSchizophrenialong noncoding RNA DGCR5, humanRNA, Long Noncoding

Identifiers

PMID30545965
PMCPMC6487854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.