ArticleScience translational medicine2018
The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
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- Identification of important gene signatures in schizophrenia through feature fusion and genetic algorithm.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
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- Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia.eLife · 2024Article
- Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.Translational psychiatry · 2024Article
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Corrections and comments
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Authors and funding
27 authors at 8 institutions in 3 countries.
Chao ChenCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China. chenchao@sklmg.edu.cn liuch@upstate.edu.ORCID 0000-0002-5114-2282
Qingtuan MengCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0002-6421-162X
Yan XiaCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0001-6432-9911
Chaodong DingCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
Le WangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0002-6825-6614
Rujia DaiCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0002-9979-3295
Lijun ChengInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
Preethi GunaratneDepartment of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1356-5698
Shishi MinCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0003-0716-9776
Cristian CoarfaHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4183-4939
Jeffrey G ReidRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID 0000-0001-8645-4713
Chunling ZhangDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0003-2752-1028
Chuan JiaoDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.
Yi JiangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0002-1196-0280
Gina GiaseSchool of Public Health, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-0263-3592
Amber ThomasInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7346-3052
Dominic FitzgeraldInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9045-4043
Tonya BrunettiInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
Annie ShiehDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-1770-5846
Cuihua XiaCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.ORCID 0000-0002-6915-3385
Yongjun WangThe Second Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-5023-7239
Yunpeng WangNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Judith A BadnerDepartment of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4818-8631
Kevin P WhiteInstitute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6934-5793
Chunyu LiuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China. chenchao@sklmg.edu.cn liuch@upstate.edu.ORCID 0000-0002-5986-4415
Central South University · CNUniversity of Chicago · USSUNY Upstate Medical University · USBaylor College of Medicine · USRegeneron (United States) · USRush University Medical Center · USUniversity of Houston · USUniversity of Illinois Chicago · US
Funding
Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9MCis-Regulatory Epigenome Mappings in SchizophreniaU01MH103392 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, SKLAR, PAMELA · 2014 to 2017
$7.6MMolecular Profiling of SchizophreniaR01MH110921 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHESS, ANDREW J, ROUSSOS, PANAGIOTIS · 2016 to 2020
$6.9MTranscriptional and Epigenetic Signatures of Human Brain Development and AutismU01MH103339 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD, STATE, MATTHEW W. · 2014 to 2017
$6.5MRisk genetic variants and cis regulation of gene expression in Bipolar DisorderR01MH109677 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2016 to 2020
$4.6MGenetic variants affect brain gene expression and risks of psychiatric disordersU01MH103340 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU, RZHETSKY, ANDREY · 2014 to 2017
$4.3MIntegrative Genomics of the Corticolimbic Circuit in Major Depressive DisorderR01MH111721 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GOES, FERNANDO SAMPAIO, HYDE, THOMAS MICHAEL · 2017 to 2021
$4.2MMapping the role of long noncoding RNAs in gene regulatory networks in schizophreniaR01MH109715 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PINTO, DALILA · 2018 to 2022
$4.0M1/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110926 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2016 to 2019
$3.2MRNA Sequencing of the Limbic System in Bipolar DisorderR01MH105898 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HYDE, THOMAS MICHAEL, ZANDI, PETER P. · 2015 to 2018
$3.1MEpigenetic and Transcriptional Dysregulation in Autism Spectrum DisorderR01MH094714 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2011 to 2015
$2.8M2/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110927 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2016 to 2019
$2.7MNIEHS NIH HHS R01 ES024988NIMH NIH HHS P50 MH106934NIMH NIH HHS R01 MH080425NIMH NIH HHS R01 MH094714NIMH NIH HHS R01 MH105898NIMH NIH HHS R01 MH109677NIMH NIH HHS R01 MH109715NIMH NIH HHS R01 MH110905NIMH NIH HHS R01 MH110920NIMH NIH HHS R01 MH110921NIMH NIH HHS R01 MH110926NIMH NIH HHS R01 MH110927NIMH NIH HHS R01 MH110928NIMH NIH HHS R01 MH111721NIMH NIH HHS R21 MH102791NIMH NIH HHS R21 MH103877NIMH NIH HHS R21 MH105853NIMH NIH HHS R21 MH105881NIMH NIH HHS R21 MH109956NIMH NIH HHS U01 MH103339NIMH NIH HHS U01 MH103340NIMH NIH HHS U01 MH103346NIMH NIH HHS U01 MH103365NIMH NIH HHS U01 MH103392
Abstract
Schizophrenia and bipolar disorder are complex psychiatric diseases with risks contributed by multiple genes. Dysregulation of gene expression has been implicated in these disorders, but little is known about such dysregulation in the human brain. We analyzed three transcriptome datasets from 394 postmortem brain tissue samples from patients with schizophrenia or bipolar disorder or from healthy control individuals without a known history of psychiatric disease. We built genome-wide coexpression networks that included microRNAs (miRNAs). We identified a coexpression network module that was differentially expressed in the brain tissue from patients compared to healthy control individuals. This module contained genes that were principally involved in glial and neural cell genesis and glial cell differentiation, and included schizophrenia risk genes carrying rare variants. This module included five miRNAs and 545 mRNAs, with six transcription factors serving as hub genes in this module. We found that the most connected transcription factor gene
Indexed as
Gene Regulatory NetworksBrainCell DifferentiationCell ProliferationDatabases, GeneticGene Expression RegulationGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHomeodomain ProteinsHumansMental DisordersNeural Stem CellsPostmortem ChangesPOU Domain FactorsReproducibility of ResultsHomeodomain ProteinsPOU Domain FactorsRNA, Messengertranscription factor Brn-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.