ArticleJournal of lipid research2019
Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids.
Open access · hybridAbstract read
In one paragraph
Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects.Clinical and translational science · 2019Trial
- Nitrated fatty acids protect against acute kidney injury in sickle cell disease.Blood advances · 2025Article
- Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice.Nature communications · 2025Article
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- Development of nitroalkene-based inhibitors to target STING-dependent inflammation.Redox biology · 2024Article
- Digestive interaction between dietary nitrite and dairy products generates novel nitrated linolenic acid products.Food chemistry · 2024Article
- Neuroprotective actions of a fatty acid nitroalkene in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Nitrated Fatty-Acids Distribution in Storage Biomolecules duringAntioxidants (Basel, Switzerland) · 2022Article
- Chemoproteomic profiling reveals cellular targets of nitro-fatty acids.Redox biology · 2021Article
- Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONORedox biology · 2021Article
- Mass spectrometry-based study defines the human urine nitrolipidome.Free radical biology & medicine · 2021Article
- Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.Toxicology and applied pharmacology · 2020Article
- Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest.Redox biology · 2020Article
- Endogenous Biosynthesis of S-Nitrosoglutathione From Nitro-Fatty Acids in Plants.Frontiers in plant science · 2020Article
- A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes.Redox biology · 2020Article
- Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology.Trends in endocrinology and metabolism: TEM · 2019Review
- Redox properties and human serum albumin binding of nitro-oleic acid.Redox biology · 2019Article
- Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.Physiological genomics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Marco FazzariFondazione Ri.MED, 90133 Palermo, Italy maf167@pitt.edu.ORCID 0000-0002-4051-4431
Dario A VitturiDepartment of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0003-0354-4567
Steven R WoodcockDepartment of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, PA 15261.
Sonia R SalvatoreDepartment of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, PA 15261.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, PA 15261.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-9526-695X
University of Pittsburgh · US
Funding
Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2011 to 2020
$26.1MTranslational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2005 to 2017
$12.5MTranslational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3MRedox-Derived Pulmonary Anti-Inflammatory MediatorsR01HL064937 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2000 to 2015
$5.6MRedox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2MFormation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4MNITRIC OXIDE REGULATION OF VASCULAR OXIDANT INJURYR01HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 1998 to 2007
$3.3MAnti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9MPredominant protective role in hepatic steatosis and obesity by fish oil-derived furansR01DK112854 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2021
$1.6MProtection against sickle cell disease nephropathy by nitrated fatty acidsK01HL133331 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VITTURI, DARIO A · 2016 to 2021
$848kNHLBI NIH HHS K01 HL133331NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL058115NHLBI NIH HHS R01 HL064937NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R37 HL058115NHLBI NIH HHS T32 HL007563NIDDK NIH HHS P30 DK072506NIDDK NIH HHS R01 DK112854NIGMS NIH HHS R01 GM125944
Abstract
Electrophilic nitro-fatty acids [NO
Indexed as
Lipid MetabolismAlkenesAnimalsBiological TransportDogsElectron TransportEsterificationFatty AcidsHydrogen-Ion ConcentrationIsomerismMaleNitro CompoundsTissue DistributionAlkenesFatty AcidsNitro Compoundsmass spectrometrynitro-fatty acidsnitro-oleic acidpharmacokineticstriglyceride
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.