ArticleMolecular pharmacology2019
Ginsenosides Act As Positive Modulators of P2X4 Receptors.
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Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors.Purinergic signalling · 2026Article
- ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases.Journal of inflammation research · 2026Review
- Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7.Purinergic signalling · 2025Article
- Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking.Heliyon · 2023Article
- Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2Journal of medicinal chemistry · 2022Article
- The P2X4 Receptor: Cellular and Molecular Characteristics of a Promising Neuroinflammatory Target.International journal of molecular sciences · 2022Review
- Piperine promotes autophagy flux by P2RX4 activation inAutophagy · 2022Article
- Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.British journal of pharmacology · 2021Review
- A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy.Nature communications · 2021Article
- Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration.Frontiers in pharmacology · 2021Review
- The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Article
- Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor.International journal of molecular sciences · 2020Review
- Resolving the Ionotropic P2X4 Receptor Mystery Points Towards a New Therapeutic Target for Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources.Frontiers in pharmacology · 2020Review
- To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?Frontiers in pharmacology · 2020Review
- Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7.Frontiers in molecular neuroscience · 2020Article
- Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Kshitija DhunaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Matthew FelgateSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Stefan M BidulaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Samuel WalpoleSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Lucka BibicSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Brett A CromerSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Jesus AnguloSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Julie SandersonSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Martin J StebbingSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).
Leanne StokesSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.) l.stokes@uea.ac.uk.
Norwich Research Park · GBRMIT University · AUFlorey Institute of Neuroscience and Mental Health · AUSwinburne University of Technology · AU
Funding
Biotechnology and Biological Sciences Research Council BB/N018427/1Biotechnology and Biological Sciences Research Council BB/P010660/1
Abstract
We investigated the selectivity of protopanaxadiol ginsenosides from
Indexed as
Adenosine TriphosphateAnimalsBenzoxazolesCalciumCell DeathCell LineGinsenosidesHEK293 CellsHumansIvermectinMiceMicrogliaQuinolinium CompoundsReceptors, Purinergic P2X4Receptors, Purinergic P2X7SapogeninsAdenosine TriphosphateBenzoxazolesCalciumGinsenosidesIvermectinprotopanaxadiolQuinolinium CompoundsReceptors, Purinergic P2X4Receptors, Purinergic P2X7SapogeninsYO-PRO 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.