Evidence map›Paper›PMID 30545923›Full record

Trial reportHaematologica2019

Azacitidine with or without lenalidomide in higher risk myelodysplastic syndrome & low blast acute myeloid leukemia.

Melita Kenealy, Mark Hertzberg, Warwick Benson, Kerry Taylor, Ilona Cunningham, Will Stevenson, Devendra Hiwase, Richard Eek, Daniela Zantomio, Steve Jong and 6 more

Open access · goldAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Favorable outcomes ofEJHaem · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 3 countries.

Melita KenealyCabrini Health, Melbourne melita.kenealy@thebloodunit.com.au.
Mark HertzbergPrince of Wales Hospital, Randwick, Sydney.
Warwick BensonWestmead Hospital, Sydney.
Kerry TaylorIcon Cancer Care, Brisbane.
Ilona CunninghamConcord Hospital University of Sydney.
Will StevensonRoyal North Shore Hospital, St Leonards.
Devendra HiwaseHaematology Department, Royal Adelaide Hospital.
Richard EekBorder Medical Oncology, Albury.
Daniela ZantomioAustin Health, Melbourne.
Steve JongAndrew Love Cancer Centre, University Hospital, Geelong.
Meaghan WallVictorian Cancer Cytogenetics Service, St Vincent's Hospital, Fitzroy, Victoria.
Piers BlomberyPeter MacCallum Cancer Centre, Melbourne.
Tracey GerberAustralasian Leukaemia and Lymphoma Group, Richmond.
Marlyse DebrincatAustralasian Leukaemia and Lymphoma Group, Richmond.
Diana ZanninoAustralasian Leukaemia and Lymphoma Group, Richmond.
John F SeymourPeter MacCallum Cancer Centre, Melbourne.
Australasian Leukaemia and Lymphoma Group · AUPeter MacCallum Cancer Centre · AUAustin Health · AUBreast Cancer Care · GBConcord Hospital · USGeelong Hospital · AUMonash University · AUPrince of Wales Hospital · AURoyal Adelaide Hospital · AURoyal North Shore Hospital · AUSt Vincents Institute of Medical Research · AUThe University of Melbourne · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standard treatment for higher risk myelodysplastic syndromes, chronic myelomonocytic leukemia and low blast acute myeloid leukemia is azacitidine. In single arm studies, adding lenalidomide had been suggested to improve outcomes. The ALLG MDS4 phase II trial randomized such patients to standard azacitidine or combination azacitidine (75mg/m

Indexed as

Blast CrisisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteMyelodysplastic SyndromesAgedAged, 80 and overAzacitidineDisease-Free SurvivalFemaleFollow-Up StudiesHumansLenalidomideMaleMiddle AgedRisk FactorsSurvival RateAzacitidineLenalidomide

Identifiers

PMID30545923
PMCPMC6442982
OpenAlexW2904574204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.