Evidence map›Paper›PMID 30545920›Full record

ArticleCancer research2019

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.

Livingstone Fultang, Laura D Gamble, Luciana Gneo, Andrea M Berry, Sharon A Egan, Fenna De Bie, Orli Yogev, Georgina L Eden, Sarah Booth, Samantha Brownhill and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Molecular profiling of core immune-escape genes highlights TNFAIP3 as an immune-related prognostic biomarker in neuroblastoma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  15. Review
  16. Article
  17. Targeting the myeloid microenvironment in neuroblastoma.Journal of experimental & clinical cancer research : CR · 2023
    Review
  18. Article
  19. Article
  20. Metabolism, metabolites, and macrophages in cancer.Journal of hematology & oncology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 5 countries.

Livingstone FultangInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Laura D GambleChildren's Cancer Institute, University of New South Wales, Sydney, Australia.ORCID 0000-0001-8496-9705
Luciana GneoInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1890-2665
Andrea M BerryChildren's Cancer Research Group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Sharon A EganSchool of Veterinary Medicine and Science, Sutton Bonington Campus, University of Nottingham, Nottingham, UK.ORCID 0000-0001-6821-6690
Fenna De BieInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Orli YogevThe Institute of Cancer Research, London, UK.
Georgina L EdenChildren's Cancer Institute, University of New South Wales, Sydney, Australia.
Sarah BoothInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Samantha BrownhillChildren's Cancer Research Group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Ashley VardonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Carmel M McConvilleInstitute of Cancer Genomic Sciences, University of Birmingham, Birmingham, Birmingham, UK.
Paul N ChengBio-Cancer Treatment International, Hong Kong.
Murray D NorrisChildren's Cancer Institute, University of New South Wales, Sydney, Australia.ORCID 0000-0002-0632-4589
Heather C EtcheversGMGF, Aix Marseille University, INSERM, Marseille, France.
Jayne MurrayChildren's Cancer Institute, University of New South Wales, Sydney, Australia.
David S ZieglerChildren's Cancer Institute, University of New South Wales, Sydney, Australia.
Louis CheslerThe Institute of Cancer Research, London, UK.
Ronny SchmidtSciomics GmbH, Heidelberg, Germany.
Susan A BurchillChildren's Cancer Research Group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Michelle HaberChildren's Cancer Institute, University of New South Wales, Sydney, Australia.ORCID 0000-0003-2036-8817
Carmela De SantoInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Francis MussaiInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. francis.mussai@nhs.net.
NIHR Birmingham Biomedical Research Centre · GBCancer Institute of New South Wales · AUUniversity of Leeds · GBCancer Research UK · GBCancer Research UK Clinical Trials Unit · GBHeidelberg Engineering (Germany) · DEInserm · FRInternational Network for Cancer Treatment and Research · BEUniversity of Nottingham · GB

Funding

Cancer Research UK 17973Cancer Research UK 23961
6 · The paper itself

Abstract

Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake

Indexed as

AnimalsArginaseArginineCell Line, TumorHumansInterleukin-1betaMacrophagesMAP Kinase Signaling SystemMiceMice, TransgenicMyeloid CellsNeuroblastomaSarcoma, EwingTumor MicroenvironmentTumor Necrosis Factor-alphaARG2 protein, humanArginaseArginineInterleukin-1betaTNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID30545920
PMCPMC6420118
OpenAlexW2904070277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.