ArticleScience (New York, N.Y.)2019
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers.
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196citing papers in PubMed
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Who cites it
196 citing papers in PubMed.
- Non-Coding Negative Regulatory Features in Livestock Genomes: Functional Annotation and Causal Validation.Animals : an open access journal from MDPI · 2026Review
- TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation.Cell stem cell · 2026Article
- Advances and clinical potential of epigenome editing.Cellular and molecular life sciences : CMLS · 2026Review
- Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers.bioRxiv : the preprint server for biology · 2026Article
- dSaCas9 enables enhanced transcriptional activation in Nicotiana benthamiana compared to its dSpCas9 ortholog.BMC plant biology · 2026Article
- Rewriting the epigenome: CRISPR tools for biological discovery and therapeutics.Current opinion in biomedical engineering · 2026Article
- KIF15 (Kinesin-12): molecular biology, physiological functions, and roles in disease.Journal of cancer research and clinical oncology · 2026Review
- The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.EMBO reports · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- CRISPR technology in ovarian cancer research: advances from gene editing to precision diagnosis and therapy.Translational cancer research · 2026Review
- The genetics of obesity: aetiology, prevention and therapy.Nature metabolism · 2026Review
- Targeted Epigenetic Activation ofBiomedicines · 2026Article
- Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR.Signal transduction and targeted therapy · 2026Article
- Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026Review
- Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope.Nature communications · 2026Article
- Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026Review
- Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Programmable transcriptional condensates for enhanced CRISPR-based gene regulation.Theranostics · 2026Article
- Genetic therapies for neurological diseases.Pharmacological reviews · 2026Review
- Degraded sensory coding in a mouse model ofbioRxiv : the preprint server for biology · 2025Article
136 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Navneet MatharuDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-9426-1484
Sawitree RattanasophaDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-3901-101X
Serena TamuraDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-3090-2385
Lenka MaliskovaDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7677-3833
Yi WangDiabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
Adelaide BernardDiabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-0050-9213
Aaron HardinDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-1231-0658
Walter L EckalbarDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Christian VaisseDiabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-4274-7033
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA. nadav.ahituv@ucsf.edu.ORCID 0000-0002-7434-8144
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MUCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MNon-coding/epigenetic regulationP01HD084387 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CAROL A WISE · 2016 to 2026
$14.2MMassively parallel reporter assays and genome editing of ENCODE predicted regulatory elementsUM1HG009408 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SHENDURE, JAY ASHOK · 2017 to 2021
$7.6MThe Melanocortin-4 Receptor in Human ObesityR01DK060540 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2002 to 2026
$7.5MObesity in Ciliopathies: How Neuronal Primary Cilia Control AppetiteR01DK106404 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, VAISSE, CHRISTIAN · 2016 to 2025
$6.6MMassively parallel dissection of psychiatric regulatory networksR01MH109907 · NIMH · J. DAVID GLADSTONE INSTITUTES · PI AHITUV, NADAV, POLLARD, KATHERINE S. · 2016 to 2020
$3.4MIntegrative interpretation of the organismal consequences of non-coding variationR01CA197139 · NCI · UNIVERSITY OF WASHINGTON · PI COOPER, GREGORY MICHAEL, SHENDURE, JAY ASHOK · 2015 to 2017
$1.9MIdentification & functional characterization of SIM1 obesity-associated variantsR01DK090382 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, VAISSE, CHRISTIAN · 2012 to 2015
$1.3MNCI NIH HHS R01 CA197139NHGRI NIH HHS UM1 HG009408NICHD NIH HHS P01 HD084387NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK060540NIDDK NIH HHS R01 DK090382NIDDK NIH HHS R01 DK106404NIGMS NIH HHS K12 GM081266NIMH NIH HHS R01 MH109907
Abstract
A wide range of human diseases result from haploinsufficiency, where the function of one of the two gene copies is lost. Here, we targeted the remaining functional copy of a haploinsufficient gene using CRISPR-mediated activation (CRISPRa) in
Indexed as
Clustered Regularly Interspaced Short Palindromic RepeatsEnhancer Elements, GeneticHaploinsufficiencyPromoter Regions, GeneticAnimalsBasic Helix-Loop-Helix ProteinsCell LineDependovirusDisease Models, AnimalFemaleGene Expression RegulationGene Transfer TechniquesHeterozygoteHypothalamusLoss of Function MutationMaleBasic Helix-Loop-Helix ProteinsMC4R protein, mouseReceptor, Melanocortin, Type 4Repressor ProteinsSim1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.