Evidence map›Paper›PMID 30545651›Full record

ArticleBioorganic & medicinal chemistry letters2019

Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT

Yulong Xu, Anna W Sromek, John L Neumeyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Identification of C10 nitrogen-containing aporphines with dopamine DBioorganic & medicinal chemistry letters · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yulong XuDivision of Basic Neuroscience, Medicinal Chemistry Program, McLean Hospital, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States.
Anna W SromekDivision of Basic Neuroscience, Medicinal Chemistry Program, McLean Hospital, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States. Electronic address: asromek@mclean.harvard.edu.
John L NeumeyerDivision of Basic Neuroscience, Medicinal Chemistry Program, McLean Hospital, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States.
Harvard University · US

Funding

F_18 Labeled D2 Agonist Ligands for PET Imaging of Dopaminergic DysfunctionR21MH103718 · NIMH · MCLEAN HOSPITAL · PI SROMEK, ANNA WACLAWA · 2014 to 2015
$507k
NIMH NIH HHS HHSN271201300017CNIMH NIH HHS R21 MH103718
6 · The paper itself

Abstract

A series of novel aporphine derivatives were synthesized for initial screening at the 5-HT

Indexed as

AporphinesHalogenationHumansLigandsMolecular StructureReceptor, Serotonin, 5-HT2CaporphineAporphinesLigandsReceptor, Serotonin, 5-HT2C5-HT(2C) receptorAporphine derivativesHit ligandsMolecular docking

Identifiers

PMID30545651
PMCPMC11492304
OpenAlexW2901035039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.