Evidence map›Paper›PMID 30545562›Full record

ArticleThe Journal of pediatrics2019

Development and Modification of an Outcome Measure to Follow Symptoms of Children with Sinusitis.

Nader Shaikh, Ellen R Wald, Jong-Hyeon Jeong, Marcia Kurs-Lasky, David Nash, Michael E Pichichero, Diana H Kearney, Mary Ann Haralam, A'Delbert Bowen, Lynda L Flom and 1 more

Registry-linked trialAbstract readValidation Study
In one paragraph

Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732699 (Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07732699 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)

TypeinterventionalSponsorNader ShaikhRan2026 to 2032Enrolled1,100ConditionsACUTE SINUSITIS, SinusitisArmsAmoxicillin, Amoxi Clavulanate, Amoxicillin Placebo, Amoxicillin-Clavulanate Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nader ShaikhDivision of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: nader.shaikh@chp.edu.
Ellen R WaldDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Jong-Hyeon JeongGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Marcia Kurs-LaskyDivision of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
David NashDivision of Allergy and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Michael E PichicheroPediatric Infectious Diseases, Rochester General Research Institute, Rochester, NY.
Diana H KearneyDivision of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Mary Ann HaralamDivision of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A'Delbert BowenDivision of Pediatric Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Lynda L FlomDivision of Pediatric Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Alejandro HobermanDivision of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Funding

Diagnosing Acute Bacterial Sinusitis in Children and Measuring Treatment ResponseR21AI076677 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAIKH, NADER · 2008 to 2009
$427k
NIAID NIH HHS R21 AI076677
6 · The paper itself

Abstract

objectiveTo develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy. STUDY

designWe developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the follow-up visit at days 10-12. Based on psychometric results and additional parent feedback, we revised the scale. We evaluated the revised version in 185 children with acute sinusitis.

resultsCorrelations between the scale and reference measures on the day of enrollment were in the expected direction and of the expected magnitude. PRSS scores at the time of presentation correlated with radiographic findings (P < .001), functional status (P < .001), and parental assessment of overall symptom severity (P < .001). Responsiveness (standardized response mean) and test-retest reliability of the revised scale were good (2.17 and 0.75, respectively).

conclusionsWe have developed an outcome measure to track the symptoms of acute sinusitis. Data presented here support the use of the PRSS as a measure of change in symptom burden in clinical trials of children with acute sinusitis.

Indexed as

Acute DiseaseChildChild, PreschoolFactor Analysis, StatisticalFemaleHumansOutcome Assessment, Health CareParentsProspective StudiesReproducibility of ResultsSinusitisoutcome measureparent-reported outcome measurepediatricssinusitissymptoms

Identifiers

PMID30545562
PMCPMC6440829

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.