ArticleBMC research notes2018
Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.BMC research notes · 2026Article
- Persistent financial adversity and cognitive aging: a life course investigation.Innovation in aging · 2026Article
- Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging.Neurology · 2025Article
- Sex differences between mid-life glycaemic traits and brain volume at age 70: a population-based study.European journal of endocrinology · 2025Article
- Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.Brain : a journal of neurology · 2025Article
- The relationship between leisure time physical activity patterns, Alzheimer's disease markers and cognition.Brain communications · 2025Article
- Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Associations between night/shift working and late-life brain health.Brain communications · 2025Article
- Sex-Dependent Effects of Cardiometabolic Health andNeurology · 2024Article
- Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Common infections and neuroimaging markers of dementia in three UK cohort studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
- Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort.Neurobiology of aging · 2023Article
- Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds.Brain communications · 2023Article
- The Power of Birth Cohorts to Study Risk Factors for Cognitive Impairment.Current neurology and neuroscience reports · 2022Review
- Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.The lancet. Healthy longevity · 2022Article
- Association between carotid atherosclerosis and brain activation patterns during the Stroop task in older adults: An fNIRS investigation.NeuroImage · 2022Article
- Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.Neurology · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectiveIdentifying and recruiting people with early pre-symptomatic Alzheimer's disease to neuroimaging research studies is increasingly important. The extent to which results of these studies can be generalised depends on the recruitment and representativeness of the participants involved. We now report the recruitment and participation patterns from a neuroscience sub-study of the MRC National Survey of Health and Development, "Insight 46". This study aimed to recruit 500 participants for extensive clinical and neuropsychological testing, and neuroimaging. We investigate how sociodemographic factors, health conditions and health-related behaviours predict participation at different levels of recruitment.
resultsWe met our target recruitment (n = 502). Higher educational attainment and non-manual socio-economic position (SEP) were consistent predictors of recruitment. Health-related variables were also predictive at every level of recruitment; in particular higher cognition, not smoking and better self-rating health. Sex and APOE-e4 status were not predictors of participation at any level. Whilst recruitment targets were met, individuals with lower SEP, lower cognition, and more health problems are under-represented in Insight 46. Understanding the factors that influence recruitment are important when interpreting results; for Insight 46 it is likely that health-related outcomes and life course risks will under-estimate those seen in the general population.
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