Observational studyArthritis research & therapy2018
Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort.
Observational study in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without.Nutrition reviews · 2025Pooled it
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Vitamin D Supplementation and Remission from Chronic Anterior Uveitis.Ocular immunology and inflammation · 2025Article
- Vitamin D status in active and inactive noninfectious uveitis - data from a reference university hospital in Rio de Janeiro, Brazil.Arquivos brasileiros de oftalmologia · 2024Article
- Can vitamin D be an adjuvant therapy for juvenile rheumatic diseases?Rheumatology international · 2023Review
- Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.Arthritis care & research · 2023Article
- Nutritional Aspects of Juvenile Idiopathic Arthritis: An A to Z for Dietitians.Children (Basel, Switzerland) · 2023Review
- Review
- Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study.BMC oral health · 2022Article
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Article
- Review
- Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study.Frontiers in pediatrics · 2022Article
- Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling.Acta dermato-venereologica · 2021Article
- Juvenile Idiopathic Arthritis Associated Uveitis.Children (Basel, Switzerland) · 2021Review
- "Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature".Journal of ophthalmic inflammation and infection · 2021Article
- Possible role of vitamin D in Covid-19 infection in pediatric population.Journal of endocrinological investigation · 2021Review
- [Register and cohort studies : Overview of the most important data sources at the German Rheumatism Research Center].Zeitschrift fur Rheumatologie · 2020Review
- [Perspectives for rheumatological health services research at the German Rheumatism Research Center].Zeitschrift fur Rheumatologie · 2020Review
- Vitamin D and Immunity in Infants and Children.Nutrients · 2020Review
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the course of JIA.
methodsPatients ≤ 16 years of age with recently diagnosed JIA (< 12 months) were enrolled in the inception cohort of patients with newly diagnosed JIA (ICON), an ongoing prospective observational, controlled multicenter study started in 2010. Clinical and laboratory parameters were ascertained quarterly during the first year and half-yearly thereafter. Of the 954 enrolled patients, 360 patients with two blood samples taken during the first 2 years after inclusion and with follow up of 3 years were selected. The serum 25(OH)D levels were determined and compared with those of subjects from the general population after matching for age, sex, migration status and the month of blood-drawing.
resultsNearly half of the patients had a deficient 25(OH)D level (< 20 ng/ml) in the first serum sample and a quarter had a deficient level in both samples. Disease activity and the risk of developing JIA-associated uveitis were inversely correlated with the 25(OH)D level (β = - 0.20, 95% CI - 0.37; 0.03, hazard ratio 0.95, 95% CI 0.91; 0.99, respectively).
conclusionIn this study, 25(OH)D deficiency was common and associated with higher disease activity and risk of developing JIA-associated uveitis. Further studies are needed to substantiate these results and determine whether correcting 25(OH)D deficiency is beneficial in JIA.
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