Evidence map›Paper›PMID 30545385›Full record

ArticleLipids in health and disease2018

Atherogenic index of plasma is a novel predictor of non-alcoholic fatty liver disease in obese participants: a cross-sectional study.

Qian Wang, Dongmei Zheng, Jia Liu, Li Fang, Qiu Li

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qian WangDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong Province, China.
Dongmei ZhengDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong Province, China.
Jia LiuDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong Province, China.
Li FangDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong Province, China.
Qiu LiDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing 5 Road, Jinan, 250021, Shandong Province, China. liqiu10@163.com.
Shandong University · CNShandong Academy of Chinese Medicine · CN

Funding

Key Research and Department of Shandong Province 2016GSF201013Key Research and Department of Shandong Province 2016GSF201015National Key Research and Development Program of China 2017YFC0909600National Key Research and Development Program of China 2017YFC1309800The Clinical Research Fund of Chinese Medical Association 15010010589The Research Fund for Public Welfare, National Health and Family Planning 201402005
6 · The paper itself

Abstract

backgroundThe atherogenic index of plasma showed to be related with some chronic disease like cardiovascular diseases and atherosclerosis. Body mass index which was commonly used in clinical practice is not an accurate index to predict non-alcoholic fatty liver disease. The aim of this study is to investigate the relationship between atherogenic index of plasma and non-alcoholic fatty liver disease in obese participants.

methods538 obese subjects were included in this cross sectional study. Non-alcoholic fatty liver disease was diagnosed by B-ultrasonography after excluding participants with other liver diseases. The atherogenic index of plasma was classified into three groups: the low (< 0.11), the intermediate (0.11-0.21) and the high (> 0.21) risk. The participants were separated into groups according to their atherogenic index of plasma levels. The area under receiver operating characteristic curve of the atherogenic index of plasma for predicting non-alcoholic fatty liver disease was calculated.

resultsThere were concordances between increased atherogenic index of plasma and significant increase in the value of body mass index, waist circumference, alanine aminotransferase, glutamyl transpeptidase and lipid profile. The atherogenic index of plasma is strongly associated with non-alcoholic fatty liver disease. Compared to the low risk group, the high risk group had a 5.37 folds risk after adjustment for covariates. Results of receiver operating characteristic curves showed that the area under the curve (95% confidence intervals) was 0.718 (0.670-0.766).

conclusionThese data suggest that atherogenic index of plasma might be a method which can be used in the auxiliary diagnosis of non-alcoholic fatty liver disease.

Indexed as

AdultAlanine TransaminaseAtherosclerosisBody Mass IndexCross-Sectional StudiesFemalegamma-GlutamyltransferaseHumansLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityRisk FactorsWaist CircumferenceAlanine Transaminasegamma-Glutamyltransferase

Identifiers

PMID30545385
PMCPMC6293612
OpenAlexW2904215727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.