ArticleBMC complementary and alternative medicine2018
Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 84 citations in OpenAlex.
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- Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice.Gut pathogens · 2022Article
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- Investigations of AGEs' inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications.Journal of natural medicines · 2022Article
- α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects ofPharmaceutical biology · 2021Article
- Phytochemical profiling and antioxidant potential ofSaudi journal of biological sciences · 2021Article
- Nontargeted Metabolomics as a Screening Tool for Estimating Bioactive Metabolites in the Extracts of 50 Indigenous Korean Plants.Metabolites · 2021Article
- Antioxidants Isolated fromMolecules (Basel, Switzerland) · 2021Article
- A scaffolded approach to unearth potential antibacterial components from epicarp of Malaysian Nephelium lappaceum L.Scientific reports · 2021Article
- Distribution of Polyphenolic and Isoprenoid Compounds and Biological Activity Differences between in the Fruit Skin + Pulp, Seeds, and Leaves of New Biotypes ofAntioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe fruit of Elaeagnus umbellata has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antioxidant, enzyme inhibitory and antidiabetic potential of Elaeagnus umbellata.
methodsThe antioxidant potential of the crude extract and subfractions of E. umbellata fruit were determined using DPPH (2, 20-diphenyl-1-picrylhydrazyl) and ABTS (2, 2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) assays. The enzyme inhibitory potentials of extracts against α-amylase and α-glucosidase enzymes were also determined. The in vivo anti-hyperglycemic effects of the extract in STZ-induced type 2 diabetes were determined using Sprague Dawley adult rats. HPLC system (Agilent 1260) was used for the identification of bioactive compounds present in extracts. Molecular docking was used to identify and compare the interaction between the compounds (active constituents) and standard inhibitor acarbose with the α-amylase and α-glucosidase active sites.
resultsThe chloroform, ethyl acetate, and butanol fractions showed significant antioxidant potential with IC
conclusionIt was concluded that E. umbellata can be used in the treatment of type 2 diabetes and oxidative stress. The extracts were also found to be effective in relieving the secondary complications associated with type 2 diabetes.
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