SynthesisBMC musculoskeletal disorders2018
Infection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Complications Associated with Bone Transport Over a Plate for Segmental Tibial Defects: A Retrospective Review of 32 Cases.Indian journal of orthopaedics · 2026Article
- Clinical features of chronic tibial osteomyelitis: a single-center retrospective study of 282 cases in Xinjiang, China.BMC musculoskeletal disorders · 2024Article
- Analysis of risk factors and development of a nomogram-based prediction model for defective bony non-union.Heliyon · 2024Article
- The Outcomes of Distraction Osteogenesis over an Intramedullary Nail for the Treatment of Bone Defects in Infectious Nonunions.The archives of bone and joint surgery · 2024Article
- Septic Tibial Nonunions on Proximal and Distal Metaphysis-A Systematic Narrative Review.Biomedicines · 2023Review
- Treatment of Infected Tibial Metaphyseal Nonunions Using the Ilizarov Method: Protocol for a Prospective Nonrandomized Study.JMIR research protocols · 2022Article
- Antibiotic cement plate composite structure internal fixation after debridement of bone infection.Scientific reports · 2021Article
- Risk factors associated with infection recurrence of posttraumatic osteomyelitis treated with Ilizarov bone transport technique-a retrospective study of 149 cases.BMC musculoskeletal disorders · 2021Article
- Role of the Ilizarov non-free bone plasty in the management of long bone defects and nonunion: Problems solved and unsolved.World journal of orthopedics · 2020Article
- Comparison of Ilizarov Bifocal, Acute Shortening and Relengthening with Bone Transport in the Treatment of Infected, Segmental Defects of the Tibia.Journal of clinical medicine · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Additionally, the prognosis factors for results of bone transportation are obscure. Therefore, this systematic review and meta-analysis was conducted to answer these questions.
methodsA systematic review was conducted following the PRISMA-IPD guidelines. Relevant publications from January 1995 to September 2018 were compiled from Medline, Embase, and Cochrane. The infection-free rates of external and hybrid fixators were achieved by synthesizing aggregate data and individual participant data (IPD). IPD was analyzed by two-stage method with logistical regression to identify prognosis factors of sequelae.
resultsTwenty-two studies with 518 patients were identified, including 11 studies with 167 patients' IPD, and 11 studies with 351 patients' aggregate data. The infection-free rate of hybrid fixator group was 86% (95%CI: 79-94%), lower than that of external fixator which was 97% (95%CI: 95-98%,). The number of previous surgeries was found predict factor of bone union sequelae (p = 0.04) and function sequelae(p < 0.01); The external fixation time was found predict factor of function sequelae (p = 0.015).
conclusionsHybrid fixators may be associated with a greater risk of infection-recurrence in the treatment of tibia infected nonunion and chronic osteomyelitis. The number of previous surgeries and external fixation time can be used as predictors of outcomes. Proper fixators and meticulously designed surgery are important to avoid unexpected operations and shorten external fixation time.
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