ArticleBMC medical genetics2018
Association of glucocorticoid receptor gene polymorphism and occupational stress with hypertension in desert petroleum workers in Xinjiang, China.
Article in BMC medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The correlation between different metabolic scores and the risk of cardiometabolic comorbidities in hypertensive patients.Scientific reports · 2025Article
- Improving Cardiovascular Health Through the Consideration of Social Factors in Genetics and Genomics Research: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular quality and outcomes · 2025Review
- Cross-sectional study on the relationship between physiologic and mental health status and hypertension risk among oil workers in Xinjiang.Frontiers in cardiovascular medicine · 2025Article
- Knowledge, Attitudes, and Practices Regarding the Prevention and Management of Acute Kidney Injury Among ICU Physicians: Association with Burnout.Journal of multidisciplinary healthcare · 2025Article
- The Interaction between Occupational Stress and Smoking, Alcohol Drinking and BMI on Hypertension in Chinese Petrochemical Workers.International journal of environmental research and public health · 2022Article
- The Association between Occupational Stress and Mental Health among Chinese Soccer Referees in the Early Stage of Reopening Soccer Matches during the COVID-19 Pandemic Outbreak: A Moderated Mediation Model.International journal of environmental research and public health · 2022Article
- Work-Related Stress, Health Status, and Status of Health Apps Use in Korean Adult Workers.International journal of environmental research and public health · 2022Article
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- Occupational stress and psychological health impact on hypertension of miners in noisy environment in Wulumuqi, China: a case-control study.BMC public health · 2020Article
- Association of intronic polymorphisms (rs1549339, rs13402242) and mRNA expression variations in PSMD1 gene in arsenic-exposed workers.Environmental science and pollution research international · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the occupational stress and hypertension in desert petroleum workers in Xinjiang, and to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.
methodsUsing cluster sampling, 1280 desert petroleum workers of 3 petroleum fields in Xinjiang Karamay were randomly selected as the target group for this study. According to the inclusion criteria, a total of 1080 workers were included as the baseline for this study. We followed these workers for 2 years to investigate their occupational stress and hypertension. The polymorphism of GR gene was detected by polymerase chain reaction-restriction fragment length polymorphism. We applied appropriate statistical methods to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.
resultsAfter 2 years of follow-up, there were 995 desert petroleum workers in the queue. The study showed that the incidence of hypertension in desert petroleum workers were 19.4%. Compared with the baseline data, the level of occupational stress increased, and with the increase of occupational stress, the incidence of hypertension was gradually increasing. A positive relationship was observed in the GR BCL1 gene polymorphisms and hypertension. Relative to the CC genotype, carries of the GG genotype had a significantly higher risk of hypertension (OR = 2.830). With the combination of genotype CG and GG, carries of CG and GG increased the risk of hypertension (adjusted OR = 2.238, 95%CI:1.104-4.940). There was no significant association between GR G678S gene polymorphisms and hypertension.
conclusionGR gene polymorphism and occupational stress of desert petroleum workers were important risk factors for hypertension.
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