Evidence map›Paper›PMID 30545158›Full record

ArticleNanomaterials (Basel, Switzerland)2018

Peptide-Templated Gold Clusters as Enzyme-Like Catalyst Boost Intracellular Oxidative Pressure and Induce Tumor-Specific Cell Apoptosis.

Ya Zhang, Xiangchun Zhang, Qing Yuan, Wenchao Niu, Chunyu Zhang, Jiaojiao Li, Zhesheng He, Yuhua Tang, Xiaojun Ren, Zhichao Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Drug delivery carriers with therapeutic functions.Advanced drug delivery reviews · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ya ZhangDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. zhangya1@ihep.ac.cn.
Xiangchun ZhangDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. zhangxc@ihep.ac.cn.
Qing YuanDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. yuanqing@bjut.edu.cn.
Wenchao NiuDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. niuwc@ihep.ac.cn.
Chunyu ZhangDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. zhangcy@ihep.ac.cn.
Jiaojiao LiDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. lijiaojiao@ihep.ac.cn.
Zhesheng HeDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. hezs@ihep.ac.cn.
Yuhua TangDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. tangyh@ihep.ac.cn.
Xiaojun RenDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. xjren@bjut.edu.cn.
Zhichao ZhangDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. zhangzc@ihep.ac.cn.
Pengju CaiDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. caipj@ihep.ac.cn.
Liang GaoDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. gaoliang@bjut.edu.cn.
Xueyun GaoDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China. gaoxy@ihep.ac.cn.
Beijing University of Technology · CN

Funding

Beijing municipal high level innovative team building program IDHT20180504National Natural Science Foundation of China 31500815, 31771082
6 · The paper itself

Abstract

Anticancer metallodrugs that aim to physiological characters unique to tumor microenvironment are expected to combat drug tolerance and side-effects. Recently, owing to the fact that reactive oxygen species' is closely related to the development of tumors, people are committed to developing metallodrugs with the capacity of improving the level of reactive oxygen species level toinduce oxidative stress in cancer cells. Herein, we demonstrated that peptide templated gold clusters with atomic precision preferably catalyze the transformation of hydrogen peroxide into superoxide anion in oxidative pressure-type tumor cells. Firstly, we successfully constructed gold clusters by rationally designing peptide sequences which targets integrin α

Indexed as

biocatalysisgold clustersoxidative pressure-type tumorreactive oxygen species

Identifiers

PMID30545158
PMCPMC6316732
OpenAlexW2905378078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.