Evidence map›Paper›PMID 30545066›Full record

ArticleJournal of clinical medicine2018

Utility of Novel Cardiorenal Biomarkers in the Prediction and Early Detection of Congestive Kidney Injury Following Cardiac Surgery.

Jason G E Zelt, Lisa M Mielniczuk, Peter P Liu, Jean-Yves Dupuis, Sharon Chih, Ayub Akbari, Louise Y Sun

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Characterizing the molecular landscape of venous congestion.World journal of critical care medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jason G E ZeltDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H8M5, Canada. jzelt@ottawaheart.ca.
Lisa M MielniczukDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H8M5, Canada. LMielniczuk@ottawaheart.ca.
Peter P LiuDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street Ottawa, ON K1Y 4W7, Canada. pliu@ottawaheart.ca.
Jean-Yves DupuisDivision of Cardiac Anesthesiology, Department of Anesthesiology and Pain Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada. jydupuis@ottawaheart.ca.
Sharon ChihDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street Ottawa, ON K1Y 4W7, Canada. schih@ottawaheart.ca.
Ayub AkbariDivision of Nephrology, Department of Medicine, The Ottawa Hospital, 1967 Riverside Dr., Ottawa, ON K1H 7W9, Canada. aakbari@toh.ca.
Louise Y SunDivision of Cardiac Anesthesiology, Department of Anesthesiology and Pain Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada. lsun@ottawaheart.ca.ORCID 0000-0003-3381-3115

Funding

Ottawa Region for Advanced Cardiovascular Research Excellence #4529
6 · The paper itself

Abstract

Acute Kidney Injury (AKI) in the context of right ventricular failure (RVF) is thought to be largely congestive in nature. This study assessed the utility of biomarkers high sensitivity cardiac troponin T (hs-cTnT), N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and neutrophil gelatinase-associated lipocalin (NGAL) for prediction and early detection of congestive AKI (c-AKI) following cardiac surgery. This prospective nested case-control study recruited 350 consecutive patients undergoing elective cardiac surgery requiring cardiopulmonary bypass. Cases were patients who developed (1) AKI (2) new or worsening RVF, or (3) c-AKI. Controls were patients free of these complications. Biomarker levels were measured at baseline after anesthesia induction and immediately postoperatively. Patients with c-AKI had increased mean duration of mechanical ventilation and length of stay in hospital and in the intensive care unit (

Indexed as

biomarkerscardiac surgerycongestive acute kidney injuryright heart failurevenous congestion

Identifiers

PMID30545066
PMCPMC6306702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.