Evidence map›Paper›PMID 30545040›Full record

ArticleInternational journal of molecular sciences2018

Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma.

Ah Ra Jung, Young-Gyu Eun, Young Chan Lee, Joo Kyung Noh, Kee Hwan Kwon

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ah Ra JungDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02774, Korea. tlsdlcl24@naver.com.ORCID 0000-0001-5647-1184
Young-Gyu EunDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02774, Korea. ygeun@khu.ac.kr.ORCID 0000-0003-4081-5207
Young Chan LeeDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02774, Korea. medchan@hanmail.net.
Joo Kyung NohDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02774, Korea. njookyung@naver.com.
Kee Hwan KwonDepartment of Otolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150, Seongan-ro Gangdong-Gu, Seoul 134-701, Korea. entkhkwon@empal.com.
Kyung Hee University · KRHallym University · KR

Funding

Kangdong Sacred Heart Hospital Fund no. 2017-03
6 · The paper itself

Abstract

Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. We analyzed the frequency of somatic mutations, clinicopathologic characteristics, association with immunotherapy-related gene signatures, and the pathways of gene signatures. We found 363 CSMD1-related genes. The prognosis of the CSMD1-inactivated subgroup was poor.

Indexed as

Cohort StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene OntologyHumansMaleMembrane ProteinsMiddle AgedMultivariate AnalysisMutationProportional Hazards ModelsSquamous Cell Carcinoma of Head and NeckTreatment OutcomeTumor Suppressor ProteinsCSMD1 protein, humanMembrane ProteinsTumor Suppressor ProteinsCSMD1gene signaturehead and neck squamous cell carcinomainactivationprognosis

Identifiers

PMID30545040
PMCPMC6321139
OpenAlexW2904618644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.