Evidence map›Paper›PMID 30544975›Full record

ArticleJournal of personalized medicine2018

Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1).

Kristin Bokelmann, Jürgen Brockmöller, Mladen V Tzvetkov

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kristin BokelmannInstitute of Clinical Pharmacology, University Medical Center, Georg-August-University, 37075 Göttingen, Germany. b.kristin@med.uni-goettingen.de.
Jürgen BrockmöllerInstitute of Clinical Pharmacology, University Medical Center, Georg-August-University, 37075 Göttingen, Germany. jbrockm@gwdg.de.
Mladen V TzvetkovInstitute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, 17487 Greifswald, Germany. mladen.tzvetkov@uni-greifswald.de.
University of Göttingen · DEUniversitätsmedizin Greifswald · DE

Funding

Deutsche Forschungsgemeinschaft DFG TZ 74/1-1
6 · The paper itself

Abstract

The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. OCT1 expression is inter-individually highly variable. Here, we analyzed SNPs in the

Indexed as

EMSAexpressionluciferase reporter gene assayNF-YOCT1promoterSNP

Identifiers

PMID30544975
PMCPMC6313513
OpenAlexW2904811131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.