Evidence map›Paper›PMID 30544923›Full record

ArticleJournal of clinical medicine2018

Validation of the REGARDS Severe Sepsis Risk Score.

Henry E Wang, John P Donnelly, Sachin Yende, Emily B Levitan, Nathan I Shapiro, Yuling Dai, Hong Zhao, Gerardo Heiss, Michelle Odden, Anne Newman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Henry E WangDepartment of Emergency Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. henry.e.wang@uth.tmc.edu.ORCID 0000-0002-4738-0093
John P DonnellyDepartment of Learning Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA. jpdonn@med.umich.edu.
Sachin YendeDepartment of Critical Care Medicine, University of Pittsburgh, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15213, USA. yendes@upmc.edu.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. eblevitan@uab.edu.
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. nshapiro@bidmc.harvard.edu.
Yuling DaiDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ydai@uabmc.edu.
Hong ZhaoDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. hozhao@uab.edu.
Gerardo HeissDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. gerardo_heiss@unc.edu.
Michelle OddenDepartment of Health Research and Policy, Stanford University, Stanford, CA 94305, USA. modden@stanford.edu.
Anne NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA. newmana@edc.pitt.edu.
Monika SaffordDepartment of Medicine, Weill-Cornell Medical Center, New York, NY 10065, USA. mms9024@med.cornell.edu.
University of Alabama at Birmingham · USUniversity of Pittsburgh · USBeth Israel Deaconess Medical Center · USCornell University · USStanford University · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · US

Funding

REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)R01HL165452 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2022 to 2025
$8.3M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0M
NHLBI NIH HHS R01 HL080477NHLBI NIH HHS R01 HL165452NHLBI NIH HHS U01 HL130114NIH HHS R01-NR012726NINDS NIH HHS UH3 NS100605
6 · The paper itself

Abstract

There are no validated systems for characterizing long-term risk of severe sepsis in community-dwelling adults. We tested the ability of the REasons for Geographic and Racial Differences in Stroke-Severe Sepsis Risk Score (REGARDS-SSRS) to predict 10-year severe sepsis risk in separate cohorts of community-dwelling adults. We internally tested the REGARDS-SSRS on the REGARDS-Medicare subcohort. We then externally validated the REGARDS-SSRS using (1) the Cardiovascular Health Study (CHS) and (2) the Atherosclerosis Risk in Communities (ARIC) cohorts. Participants included community-dwelling adults: REGARDS-Medicare, age ≥65 years,

Indexed as

infectionsoutcomesrisk predictionsepsis

Identifiers

PMID30544923
PMCPMC6306847
OpenAlexW2904311936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.