Evidence map›Paper›PMID 30544918›Full record

ReviewMicromachines2018

Nanoindentation of Soft Biological Materials.

Long Qian, Hongwei Zhao

Abstract readReview
In one paragraph

Review in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Long QianSchool of Mechanical and Aerospace Engineering, Jilin University, Changchun 130025, China. qianlong17@mails.jlu.edu.cn.
Hongwei ZhaoSchool of Mechanical and Aerospace Engineering, Jilin University, Changchun 130025, China. hwzhao@jlu.edu.cn.

Funding

Fund Guiding on Strategic Adjustment of Jilin Provincial Economic Structure Project 2014Z045Jilin Provincial Middle and Young Scientific and Technological Innovation Talent and Team Project 20170519001JHMajor Project of Jilin Province Science and Technology Development Plan 20150203014GXNational Natural Science Funds for Excellent Young Scholar 51422503Program for JLU Science and Technology Innovative Research Team 2017TD-04Special Fund Project of Jilin Provincial Industrial Innovation 2016C030Special Projects for Development of National Major Scientific Instruments and Equipments 2012YQ030075
6 · The paper itself

Abstract

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently been moved into the center of the spotlight for measuring the mechanical properties of biomaterials, especially bridging the scales from the molecular via the cellular and tissue all the way to the organ level, whereas characterizing soft biomaterials, especially down to biomolecules, is fraught with more pitfalls compared with the hard biomaterials. In this review we detail the constitutive behavior of soft biomaterials under nanoindentation (including AFM) and present the characteristics of experimental aspects in detail, such as the adaption of instrumentation and indentation response of soft biomaterials. We further show some applications, and discuss the challenges and perspectives related to nanoindentation of soft biomaterials, a technique that can pinpoint the mechanical properties of soft biomaterials for the scale-span is far-reaching for understanding biomechanics and mechanobiology.

Indexed as

atomic force microscopy (AFM)mechanical propertiesnanoindentationsoft biomaterialsviscoelasticity

Identifiers

PMID30544918
PMCPMC6316095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.