ReviewInternational journal of molecular sciences2018
Potential Role of Fluoride in the Etiopathogenesis of Alzheimer's Disease.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Fluoride and the brain: A systematic review of neurotoxicity and developmental risks.Genetics and molecular biology · 2026Article
- Antibiotic-Induced Gut Dysbiosis Modulates Alzheimer's Disease-Associated Gene Expression and Protein Aggregation in 3xTg-AD Mice via the Gut-Brain Axis.Brain and behavior · 2025Article
- Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Dose-dependent developmental fluoride exposure leads to neurotoxicity and impairs excitatory synapse development.Archives of toxicology · 2025Article
- Magnesium (Mg) and Neurodegeneration: A Comprehensive Overview of Studies on Mg Levels in Biological Specimens in Humans Affected Some Neurodegenerative Disorders with an Update on Therapy and Clinical Trials Supplemented with Selected Animal Studies.International journal of molecular sciences · 2024Review
- An in vivo and in silico probing of the protective potential of betaine against sodium fluoride-induced neurotoxicity.BMC pharmacology & toxicology · 2024Article
- Exploring the effect of gut microbiome on Alzheimer's disease.Biochemistry and biophysics reports · 2024Review
- Evaluation ofDentistry journal · 2024Article
- Assessment of Nanosilver Fluoride Application on the Microtensile Bond Strength of Glass Ionomer Cement and Resin-modified Glass Ionomer Cement on Primary Carious Dentin: AnInternational journal of clinical pediatric dentistry · 2024Article
- Fluoride - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Environmental Toxicity Assessment of Sodium Fluoride and Platinum-Derived Drugs Co-Exposure on Aquatic Organisms.Toxics · 2022Article
- Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions.Biosensors · 2022Article
- Fluoride exposure during early adolescence and its association with internalizing symptoms.Environmental research · 2022Article
- Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats.Environmental science and pollution research international · 2021Article
- Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.Oxidative medicine and cellular longevity · 2021Article
- The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer's Disease.Frontiers in pharmacology · 2021Review
- The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?Nutrients · 2020Review
- The Use of Antioxidants in the Treatment of Migraine.Antioxidants (Basel, Switzerland) · 2020Review
- Fluoride Exposure as a Possible Environmental Modifier of Idiopathic Parkinson's Disease: Insights from a Rural North Indian Cohort.International journal of applied & basic medical researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiopathogenesis of Alzheimer's disease has not been fully explained. Now, the disease is widely attributed both to genetic and environmental factors. It is believed that only a small percentage of new AD cases result solely from genetic mutations, with most cases attributed to environmental factors or to the interaction of environmental factors with preexistent genetic determinants. Fluoride is widespread in the environment and it easily crosses the blood⁻brain barrier. In the brain fluoride affects cellular energy metabolism, synthesis of inflammatory factors, neurotransmitter metabolism, microglial activation, and the expression of proteins involved in neuronal maturation. Finally, and of specific importance to its role in Alzheimer's disease, studies report fluoride-induced apoptosis and inflammation within the central nervous system. This review attempts to elucidate the potential relationship between the effects of fluoride exposure and the pathogenesis of Alzheimer's disease. We describe the impact of fluoride-induced oxidative stress and inflammation in the pathogenesis of AD and demonstrate a role for apoptosis in disease progression, as well as a mechanism for its initiation by fluoride. The influence of fluoride on processes of AD initiation and progression is complex and warrants further investigation, especially considering growing environmental fluoride pollution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.