Evidence map›Paper›PMID 30544871›Full record

ArticleViruses2018

Tet-Inducible Production of Infectious Zika Virus from the Full-Length cDNA Clones of African- and Asian-Lineage Strains.

Lizhou Zhang, Wei Ji, Shuang Lyu, Luhua Qiao, Guangxiang Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lizhou ZhangDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA. lizhou8728@gmail.com.
Wei JiDepartment of Microbiology, Peking University Health Science Center School of Basic Medical Sciences, Beijing 100191, China. jiwei_yunlong@126.com.
Shuang LyuDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA. shuanglv@uab.edu.
Luhua QiaoDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA. luhuaq@gmail.com.
Guangxiang LuoDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA. gluo@uab.edu.ORCID 0000-0002-0354-6020
University of Alabama at Birmingham · USPeking University · CN

Funding

NIH HHS AI097318
6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as an important human viral pathogen, causing congenital malformation including microcephaly among infants born to mothers infected with the virus during pregnancy. Phylogenetic analysis suggested that ZIKV can be classified into African and Asian lineages. In this study, we have developed a stable plasmid-based reverse genetic system for robust production of both ZIKV prototype African-lineage MR766 and clinical Asian-lineage FSS13025 strains using a tetracycline (Tet)-controlled gene expression vector. Transcription of the full-length ZIKV RNA is under the control of the Tet-responsive

Indexed as

Genetic VectorsPromoter Regions, GeneticReverse GeneticsAfricaAsiaCells, CulturedCloning, MolecularDNA, ComplementaryDoxycyclineGenome, ViralHepatitis Delta VirusPhylogenyPlasmidsTetracyclineVirus ReplicationZika VirusDNA, ComplementaryDoxycyclineTetracyclineFSS13025infectious cDNAMR766reverse geneticsTet-inducibleZika virus

Identifiers

PMID30544871
PMCPMC6316044
OpenAlexW2904294291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.