Evidence map›Paper›PMID 30544836›Full record

ArticleInternational journal of molecular sciences2018

Search of Allosteric Inhibitors and Associated Proteins of an AKT-

Rodrigo Ochoa, Cristian Rocha-Roa, Marcel Marín-Villa, Sara M Robledo, Rubén E Varela-M

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rodrigo OchoaPECET, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia. rodrigo.ochoa@udea.edu.co.ORCID 0000-0003-0734-2196
Cristian Rocha-RoaGEPAMOL, Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia 630004, Colombia. ccrochar@uqvirtual.edu.co.ORCID 0000-0002-4602-6121
Marcel Marín-VillaPECET, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia. marcel.marin@udea.edu.co.
Sara M RobledoPECET, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia. sara.robledo@udea.edu.co.ORCID 0000-0003-2752-4931
Rubén E Varela-MPECET, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia. ruben.varela00@usc.edu.co.ORCID 0000-0002-1635-0166
Universidad de Antioquia · COUniversity of Quindío · CO

Funding

COLCIENCIAS 111571250689Universidad Santiago de Cali DGI-912-621116-C9
6 · The paper itself

Abstract

Proteins associated to the PI3K/AKT/mTOR signaling pathway are widely used targets for cancer treatment, and in recent years they have also been evaluated as putative targets in trypanosomatids parasites, such as

Indexed as

Allosteric RegulationAnimalsLigandsModels, MolecularParasitesProtein Interaction MapsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktProtozoan ProteinsRisk FactorsTrypanosoma cruziLigandsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktProtozoan Proteinsdrug discoverypleckstrin homology domainprotein kinase BTrypanosoma cruzi

Identifiers

PMID30544836
PMCPMC6321509
OpenAlexW2905085973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.