Evidence map›Paper›PMID 30544788›Full record

ArticleMarine drugs2018

Evaluation of the Potential of Collagen from Codfish Skin as a Biomaterial for Biomedical Applications.

Ana M Carvalho, Alexandra P Marques, Tiago H Silva, Rui L Reis

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 138 citations in OpenAlex.

  1. Review
  2. Article
  3. Collagen from Marine Sources for Potential Application in Wound Treatment.Progress in molecular and subcellular biology · 2026
    Review
  4. International journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Evidence for Endogenous Collagen inAnalytical chemistry · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana M Carvalho3B's Research Group, I3Bs⁻Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine Avepark⁻Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal. ammpfc@i3bs.uminho.pt.
Alexandra P Marques3B's Research Group, I3Bs⁻Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine Avepark⁻Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal. apmarques@i3bs.uminho.pt.
Tiago H Silva3B's Research Group, I3Bs⁻Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine Avepark⁻Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal. tiago.silva@i3bs.uminho.pt.ORCID 0000-0001-8520-603X
Rui L Reis3B's Research Group, I3Bs⁻Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine Avepark⁻Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal. rgreis@i3bs.uminho.pt.
University of Minho · PT

Funding

European Research Council ERC-2012-ADG 20120216-321266
6 · The paper itself

Abstract

Collagen is one of the most widely used biomaterials, not only due its biocompatibility, biodegradability and weak antigenic potential, but also due to its role in the structure and function of tissues. Searching for alternative collagen sources, the aim of this study was to extract collagen from the skin of codfish, previously obtained as a by-product of fish industrial plants, and characterize it regarding its use as a biomaterial for biomedical application, according to American Society for Testing and Materials (ASTM) Guidelines. Collagen type I with a high degree of purity was obtained through acid-extraction, as confirmed by colorimetric assays, SDS-PAGE and amino acid composition. Thermal analysis revealed a denaturing temperature around 16 °C. Moreover, collagen showed a concentration-dependent effect in metabolism and on cell adhesion of lung fibroblast MRC-5 cells. In conclusion, this study shows that collagen can be obtained from marine-origin sources, while preserving its bioactivity, supporting its use in biomedical applications.

Indexed as

GadiformesAnimalsBiocompatible MaterialsCell AdhesionCell LineCollagen Type IFibroblastsHumansLiquid-Liquid ExtractionMaterials TestingSkinBiocompatible MaterialsCollagen Type IASTM guidelinesbiologic activitybiomedical applicationbiophysical characterizationcodfishmarine biomaterialsmarine-origin collagen

Identifiers

PMID30544788
PMCPMC6316778
OpenAlexW2905331224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.