Evidence map›Paper›PMID 30544651›Full record

ArticleInternational journal of environmental research and public health2018

Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment.

Devon C Payne-Sturges, Madeleine K Scammell, Jonathan I Levy, Deborah A Cory-Slechta, Elaine Symanski, Jessie L Carr Shmool, Robert Laumbach, Stephen Linder, Jane E Clougherty

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  2. FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Effects of air pollution exposure on social behavior: a synthesis and call for research.Environmental health : a global access science source · 2021
    Review
  14. Article
  15. Framing Environmental Health Decision-Making: The Struggle over Cumulative Impacts Policy.International journal of environmental research and public health · 2021
    Article
  16. Accounting for Health Risk Inequality in Regulatory Impact Analysis: Barriers and Opportunities.Risk analysis : an official publication of the Society for Risk Analysis · 2021
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Devon C Payne-SturgesMaryland Institute for Applied Environmental Health, University of Maryland School of Public Health, 2234 L SPH, 255 Valley Drive, College Park, MD 20742, USA. dps1@umd.edu.
Madeleine K ScammellDepartment of Environmental Health, Boston University School of Public Health, 715 Albany St., TW4, Boston, MA 02118, USA. mls@bu.edu.ORCID 0000-0003-3836-083X
Jonathan I LevyDepartment of Environmental Health, Boston University School of Public Health, 715 Albany St., TW4, Boston, MA 02118, USA. jonlevy@bu.edu.ORCID 0000-0002-1116-4006
Deborah A Cory-SlechtaDepartment of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA. deborah_cory-slechta@urmc.rochester.edu.
Elaine SymanskiThe Southwest Center for Occupational and Environmental Health, Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Pressler Street, Suite W-1030, Houston, TX 77030, USA. elaine.symanski@uth.tmc.edu.
Jessie L Carr ShmoolDepartment of Environmental & Occupational Health, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA. jessielcarr@gmail.com.
Robert LaumbachEnvironmental and Occupational Health Sciences Institute, Rutgers School of Public Health, 170 Frelinghuysen Rd, room 204, Piscataway, NJ 08854, USA. laumbach@eohsi.rutgers.edu.
Stephen LinderInstitute for Health Policy, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler, Houston, TX 77030, USA. stephen.h.linder@uth.tmc.edu.ORCID 0000-0003-1316-4496
Jane E CloughertyDornsife School of Public Health, Drexel University, 3215 Market Street, Nesbitt Hall, Office 616, Philadelphia, PA 19104, USA. jcloughe@drexel.edu.ORCID 0000-0002-9911-1565

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Cumulative risk assessment (CRA) has been proposed as a means of evaluating possible additive and synergistic effects of multiple chemical, physical and social stressors on human health, with the goal of informing policy and decision-making, and protecting public health. Routine application of CRA to environmental regulatory and policy decision making, however, has been limited due to a perceived lack of appropriate quantitative approaches for assessing combined effects of chemical and nonchemical exposures. Seven research projects, which represented a variety of disciplines, including population health science, laboratory science, social sciences, geography, statistics and mathematics, were funded by the US Environmental Protection Agency (EPA) to help address this knowledge gap. We synthesize key insights from these unique studies to determine the implications for CRA practice and priorities for further research. Our analyses of these seven projects demonstrate that the necessary analytical methods to support CRA are available but are ultimately context-dependent. These projects collectively provided advancements for CRA in the areas of community engagement, characterization of exposures to nonchemical stressors, and assessment of health effects associated with joint exposures to chemical and psychosocial stressors.

Indexed as

Decision MakingEnvironmental ExposureEnvironmental HealthEnvironmental PollutantsHumansRisk AssessmentStress, PsychologicalUnited StatesEnvironmental Pollutantscommunity healthcumulative riskenvironmental justicemethodspsychosocial stressors

Identifiers

PMID30544651
PMCPMC6313653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.