Evidence map›Paper›PMID 30544643›Full record

ArticleGenes2018

Generation of A Mucor circinelloides Reporter Strain-A Promising New Tool to Study Antifungal Drug Efficacy and Mucormycosis.

Ulrike Binder, Maria Isabel Navarro-Mendoza, Verena Naschberger, Ingo Bauer, Francisco E Nicolas, Johannes D Pallua, Cornelia Lass-Flörl, Victoriano Garre

Open access · goldAbstract read
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Journal of fungi (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Recent Advances and Future Directions in the Understanding of Mucormycosis.Frontiers in cellular and infection microbiology · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Genetic Modification ofFrontiers in nutrition · 2021
    Article
  15. The Added Value of Longitudinal Imaging for PreclinicalAntimicrobial agents and chemotherapy · 2020
    Article
  16. CRISPR-Cas9-Based Mutagenesis of the Mucormycosis-Causing FungusInternational journal of molecular sciences · 2020
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ulrike BinderDivision of Hygiene and Medical Microbiology, Medical University Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria. ulrike.binder@i-med.ac.at.ORCID 0000-0002-2160-2903
Maria Isabel Navarro-MendozaDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain. mariaisabel.navarro3@um.es.ORCID 0000-0002-3560-6155
Verena NaschbergerDivision of Hygiene and Medical Microbiology, Medical University Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria. verena.naschberger@i-med.ac.at.
Ingo BauerDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. ingo.bauer@i-med.ac.at.ORCID 0000-0002-3316-7769
Francisco E NicolasDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain. fnicolas@um.es.
Johannes D PalluaInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Müllerstraße 44, 6020 Innsbruck, Austria. johannes.pallua@i-med.ac.at.
Cornelia Lass-FlörlDivision of Hygiene and Medical Microbiology, Medical University Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria. cornelia.lass-floerl@i-med.ac.at.
Victoriano GarreDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain. vgarre@um.es.ORCID 0000-0001-7605-1726
Innsbruck Medical University · ATUniversidad de Murcia · ES

Funding

European Molecular Biology Organization 6856
6 · The paper itself

Abstract

Invasive fungal infections caused by Mucorales (mucormycosis) have increased worldwide. These life-threatening infections affect mainly, but not exclusively, immunocompromised patients, and are characterized by rapid progression, severe tissue damage and an unacceptably high rate of mortality. Still, little is known about this disease and its successful therapy. New tools to understand mucormycosis and a screening method for novel antimycotics are required. Bioluminescent imaging is a powerful tool for in vitro and in vivo approaches. Hence, the objective of this work was to generate and functionally analyze bioluminescent reporter strains of

Indexed as

bioluminescencefirefly luciferaseMucor circinelloidesmucormycosisreporter strain

Identifiers

PMID30544643
PMCPMC6315630
OpenAlexW2905298579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.