ReviewThe international journal of neuropsychopharmacology2019
Making Sense of Connectivity.
Review in The international journal of neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Comparing three methodologies for network analysis of human [EJNMMI research · 2025Article
- Resting-State and Task-Based Functional Connectivity Reveal Distinct mPFC and Hippocampal Network Alterations in Major Depressive Disorder.Brain sciences · 2025Article
- The Connectivity of the Resting Brain in Primary Open-Angle Glaucoma: A Systematic Review.Biomedicines · 2025Review
- Article
- Tell me why: A scoping review on the fundamental building blocks of fMRI-based network analysis.NeuroImage. Clinical · 2025Article
- Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Audiovisual integration and whole-brain networks in preterm and full-term neonates: A two-layer multiplex network perspective on structural and functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Human Claustrum Connections: Robust In Vivo Detection by DWI-Based Tractography in Two Large Samples.Human brain mapping · 2024Article
- A new framework for metabolic connectivity mapping using bolus [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Move Your Body, Boost Your Brain: The Positive Impact of Physical Activity on Cognition across All Age Groups.Biomedicines · 2023Review
- Brain connectomics: time for a molecular imaging perspective?Trends in cognitive sciences · 2023Review
- Parkinson's disease progression: Increasing expression of an invariant common core subnetwork.NeuroImage. Clinical · 2023Article
- Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans.Therapeutic advances in psychopharmacology · 2022Article
- Evaluating global brain connectivity as an imaging marker for depression: influence of preprocessing strategies and placebo-controlled ketamine treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- From metabolic connectivity to molecular connectivity: application to dopaminergic pathways.European journal of nuclear medicine and molecular imaging · 2020Article
- Clinically feasible brain morphometric similarity network construction approaches with restricted magnetic resonance imaging acquisitions.Network neuroscience (Cambridge, Mass.) · 2020Article
- Brain Molecular Connectivity in Neurodegenerative Diseases: Recent Advances and New Perspectives Using Positron Emission Tomography.Frontiers in neuroscience · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to the assessment of local alterations of specific brain regions, the investigation of entire networks with in vivo neuroimaging techniques has gained increasing attention. In general, connectivity analysis refers to the investigation of links between brain regions, with the aim to characterize their interactions and information transfer. These may represent or relate to different physiological characteristics (structural, functional, or metabolic information) and can be calculated across different levels of granularity (2 regions vs whole brain). In this article, we provide an overview of different connectivity analysis approaches with interpretations and limitations as well as examples in pharmacological imaging and clinical applications. Structural connectivity obtained from diffusion MRI enables the reconstruction of neuronal fiber tracts. These physical links represent major constraints of functional connections, which are in turn defined as correlations between signal time courses. In addition, molecular connectivity approaches based on PET imaging enable the assessment of interregional associations of metabolic demands and neurotransmitter systems. Application of these approaches in clinical investigations has demonstrated novel alterations in various neurological and psychiatric disorders on a network level. Future work should aim for the combined assessment of multiple imaging modalities and to establish robust biomarkers for clinical use. These advancements will further improve the biological interpretation of connectivity metrics and networks of the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.