Evidence map›Paper›PMID 30544114›Full record

ArticleAmerican journal of nephrology2019

Trends in Opioid Prescribing Among Hemodialysis Patients, 2007-2014.

Matthew Daubresse, G Caleb Alexander, Deidra C Crews, Dorry L Segev, Mara A McAdams-DeMarco

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Opioids in Hemodialysis Patients.Seminars in nephrology · 2021
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Matthew DaubresseDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
G Caleb AlexanderDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Deidra C CrewsDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dorry L SegevDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Mara A McAdams-DeMarcoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, mara@jhu.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Cardiometabolic Health in Adolescents of South Asian Ancestry - the CHAriSmA studyR01DK115648 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MAGGE, SHEELA NATESH · 2018 to 2022
$3.9M
Hemodialysis-based interventions to preserve cognitive functionR01DK114074 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2018 to 2022
$3.9M
Community-Based Dietary Approach for Hypertensive African Americans with Chronic Kidney DiseaseU01MD010550 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE, MILLER, EDGAR RAYMOND · 2016 to 2020
$2.9M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty and Adverse Health Outcomes of Aging in Older Adults with Kidney FailureK01AG043501 · NIA · JOHNS HOPKINS UNIVERSITY · PI MCADAMS DEMARCO, MARA A. · 2014 to 2018
$624k
Patient-Oriented Research Addressing Disparities in Hypertension and Kidney DiseaseK24HL148181 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 2019 to 2023
$541k
NHLBI NIH HHS K24 HL148181NIA NIH HHS K01 AG043501NIA NIH HHS R01 AG055781NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK114074NIDDK NIH HHS R01 DK115648NIDDK NIH HHS T32 DK062707NIMHD NIH HHS U01 MD010550
6 · The paper itself

Abstract

backgroundHemodialysis (HD) patients frequently experience pain. Previous studies of HD patients suggest increased opioid prescribing through 2010. It remains unclear if this trend continued after 2010 or declined with national trends.

methodsLongitudinal cohort study of 484,745 HD patients in the United States Renal Data System/Medicare data. We used Poisson/negative binomial regression to estimate annual incidence rates of opioid prescribing between 2007 and 2014. We compared prescribing rates with the general US population using IQVIA's National Prescription Audit data. Outcomes included the following: percent of HD patients receiving an opioid prescription, rate of opioid prescriptions, quantity, days supply, morphine milligram equivalents (MME) dispensed per 100 person-days, and prescriptions per person.

resultsIn 2007, 62.4% of HD patients received an opioid prescription. This increased to 63.2% in 2010 then declined to 53.7% by 2014. Opioid quantity peaked in 2011 at 73.5 pills per 100 person-days and declined to 62.6 pills per 100 person-days in 2014. MME peaked between 2010 and 2012 then declined through 2014. In 2014, MME rates were 1.8-fold higher among non-Hispanic patients and 1.6-fold higher among low-income patients. HD patients received 3.2-fold more opioid prescriptions per person compared to the general US population and were primarily prescribed oxycodone and hydrocodone. Between 2012 and 2014, HD patients experienced greater declines in opioid prescriptions per person (18.2%) compared to the general US population (7.1%).

conclusionOpioid prescribing among HD patients declined between 2012 and 2014. However, HD patients continue receiving substantially more opioids than the general US population.

Indexed as

AdolescentAdultAgedAnalgesics, OpioidDrug PrescriptionsFemaleHumansKidney Failure, ChronicLongitudinal StudiesMaleMedicareMiddle AgedPainPractice Patterns, Physicians'Renal DialysisRetrospective StudiesAnalgesics, OpioidHemodialysisOpioid prescribingTrendsUnited States

Identifiers

PMID30544114
PMCPMC6341485
OpenAlexW2904713947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.