ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2019
Hypoglycemia but Not Hyperglycemia Is Associated with Mortality in Critically Ill Patients with Diabetes.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of hypoglycaemia with the risks of arrhythmia and mortality in individuals with diabetes - a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults.Geriatrics (Basel, Switzerland) · 2026Review
- Glycemic Status and Glycemic Variability Related to Mortality and Morbidity in Critically III Diabetic and Non-Diabetic Patients: A Prospective Observational Study.Clinics and practice · 2026Article
- What Is the Role of Diabetic Alert Dogs in Glycemic Monitoring for Individuals with Type 1 Diabetes? A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- U-shaped association of the stress hyperglycemia ratio with all-cause mortality and premature death in patients with cardiovascular disease: a cohort study.Diabetology & metabolic syndrome · 2025Article
- Glucose management in critically ill adults: A qualitative study from the experiences of health care providers.Heliyon · 2024Article
- Hypoglycemia in patients with type 2 diabetes mellitus during hospitalization: associated factors and prognostic value.Diabetology & metabolic syndrome · 2023Article
- Glycemic variability and mortality in oncologic intensive care units.Revista brasileira de enfermagem · 2023Article
- Clinical Management of Diabetes Mellitus in the Era of COVID-19: Practical Issues, Peculiarities and Concerns.Journal of clinical medicine · 2020Review
- Reply to the Letter to the Editor "Hypoglycemia and Mortality in Critically Ill Patients with Type 2 Diabetes".Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
- Hypoglycemia and Mortality in Critically Ill Patients with Type 2 Diabetes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
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14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth severe hyperglycemia (> 200 mg/dL) and hypoglycemia (≤70 mg/dL) are known to be associated with increased mortality in critically ill patients. Therefore, we investigated associations of a single episode of blood glucose deviation (concentration either ≤70 mg/dL and/or > 200 mg/dL) during an intensive care unit (ICU) stay with mortality in these patients.
methodsA total of 4,986 patients (age 65 ± 15 years; 39% female; 14% type 2 diabetes [T2DM] based on medical records) admitted to a German ICU in a tertiary care hospital were investigated retrospectively. The intra-ICU and long-term mortality of patients between 4 and 7 years after their ICU submission were assessed.
resultsA total 62,659 glucose measurements were analyzed. A single glucose deviation was associated with adverse outcomes compared to patients without a glucose deviation, represented by both intra-ICU mortality (22 vs. 10%; OR 2.62; 95% CI 2.23-3.09; p < 0.001) and long-term mortality (HR 2.01; 95% CI 1.81-2.24; p < 0.001). In patients suffering from T2DM hypoglycemia (30 vs. 13%; OR 2.94; 95% CI 2.28-3.80; p < 0.001) but not hyperglycemia (16 vs. 14%; OR 1.05; 95% CI 0.68-1.62; p = 0.84) was associated with mortality.
conclusionIn patients with dia-betes, hypo- but not hyperglycemia was associated with increased mortality, whereas in patients without diabetes, both hyper- and hypoglycemia were associated with adverse outcome. Blood glucose concentration might need differential approaches depending on concomitant diseases.
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