Evidence map›Paper›PMID 30544077›Full record

ArticleEuropean journal of medicinal chemistry2019

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Bo Wu, Selwyn S Jayakar, Xiaojuan Zhou, Katherine Titterton, David C Chiara, Andrea L Szabo, Pavel Y Savechenkov, Daniel E Kent, Jonathan B Cohen, Stuart A Forman and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Immunohistochemical distribution of 10 GABAThe Journal of comparative neurology · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Bo WuDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.
Selwyn S JayakarDepartment of Neurobiology, 220 Longwood Avenue, Harvard Medical School, Boston, MA, 02115, USA.
Xiaojuan ZhouDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA.
Katherine TittertonDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA.
David C ChiaraDepartment of Neurobiology, 220 Longwood Avenue, Harvard Medical School, Boston, MA, 02115, USA.
Andrea L SzaboDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA.
Pavel Y SavechenkovDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.
Daniel E KentDepartment of Health Science, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA.
Jonathan B CohenDepartment of Neurobiology, 220 Longwood Avenue, Harvard Medical School, Boston, MA, 02115, USA.
Stuart A FormanDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA.
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA; Department of Biological Chemistry and Molecular Pharmacology, 220 Longwood Avenue, Harvard Medical School, Boston, MA, 02115, USA.
Karol S BruzikDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA. Electronic address: kbruzik@uic.edu.
Massachusetts General Hospital · USHarvard University · USUniversity of Illinois Chicago · USNortheastern University · US

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
Mechanism of Calcium-Dependent Phospholipases CR01GM057568 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BRUZIK, KAROL S · 1999 to 2008
$1.9M
NIGMS NIH HHS P01 GM058448NIGMS NIH HHS R01 GM057568
6 · The paper itself

Abstract

Pregnanolone and allopregnanolone-type ligands exert general anesthetic, anticonvulsant and anxiolytic effects due to their positive modulatory interactions with the GABA

Indexed as

AnestheticsBinding SitesDiazomethaneHumansNeurotransmitter AgentsPhotoaffinity LabelsProtein SubunitsReceptors, GABA-AAnestheticsDiazomethaneNeurotransmitter AgentsPhotoaffinity LabelsProtein SubunitsReceptors, GABA-AAnesthetic NeurosteroidsDiazirineGABA-A Receptor ModulatorsGeneral Anesthetics Binding SitesPhotolabeling

Identifiers

PMID30544077
PMCPMC6912599
OpenAlexW2901485004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.