ArticlePloS one2018
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 100 citations in OpenAlex.
- In Vivo Measurement of Taurine With Optimized Double-Quantum Filtering Magnetic Resonance Spectroscopy.Magnetic resonance in medicine · 2026Article
- Multiple Modelling Methods Suggest That Grain-Free Diets Are Not Predictive of New Owner-Reported Cardiac Diagnoses Over Two Years in the Dog Aging Project, Despite Owner Misclassification of Diet.Veterinary medicine and science · 2026Article
- Bioactive Collagen Peptides in Veterinary and Biomedical Science-Part II: The Gut-Collagen Peptide Axis, Bile Acid Signaling, and Translational Therapeutic Applications.Veterinary sciences · 2026Review
- Plasma Metabolite Profiles of Exercising American Foxhound Dogs Fed Different Diets.Metabolites · 2026Article
- From functional ingredients to bioactive compounds: a review of their role in commercial pet food.Veterinary research communications · 2026Review
- Taurine in canine physiology and metabolic regulation.Frontiers in veterinary science · 2026Review
- Preliminary Analysis of Intestinal Microbiota in Golden Retrievers Prone to Dilated Cardiomyopathy Due to Taurine Deficiency.Veterinary sciences · 2025Article
- Role of Diet as a Predisposing Factor for Dilated Cardiomyopathy in Dogs: A Narrative Review.Veterinary sciences · 2025Review
- Determination of Retinol, Cholecalciferol, α-Tocopherol and Phylloquinone Levels in Dogs with Dilated Cardiomyopathy: A Preliminary Study.Animals : an open access journal from MDPI · 2025Article
- Grain-Free Diets for Dogs and Cats: An Updated Review Focusing on Nutritional Effects and Health Considerations.Animals : an open access journal from MDPI · 2025Review
- Transthoracic echocardiographic reference intervals in 214 adult Golden retrievers.The Journal of veterinary medical science · 2025Article
- Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs.Journal of animal science · 2025Article
- Whole pulse ingredient inclusion in macronutrient-balanced diets increased fecal concentrations of propionic acid but not total bile acids in healthy adult large-breed dogs after 20 weeks.Journal of animal science · 2025Article
- Nutritional analysis of commercially available, complete plant- and meat-based dry dog foods in the UK.PloS one · 2025Article
- Article
- Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year.PloS one · 2024Article
- Lentils pasta by-product in a complete extruded diet for dogs and its effect on extrusion, digestibility, and carbohydrate metabolism.Frontiers in veterinary science · 2024Article
- Quantitative bile acid profiling in healthy adult dogs and pups from serum, plasma, urine, and feces using LC-MS/MS.Frontiers in veterinary science · 2024Article
- Fecal microbiota composition, serum metabolomics, and markers of inflammation in dogs fed a raw meat-based diet compared to those on a kibble diet.Frontiers in veterinary science · 2024Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGolden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation.
objectiveTo describe the clinical, dietary, and echocardiographic features in golden retrievers diagnosed with taurine deficiency and dilated cardiomyopathy, and to determine specific dietary associations. A second aim was to determine the whole blood taurine concentrations in a representative sample of healthy golden retrievers. ANIMALS: Twenty-four client-owned golden retrievers with documented taurine deficiency and dilated cardiomyopathy and 52 healthy client-owned golden retrievers.
methodsIn this multicenter prospective observational study, baseline and follow-up echocardiographic data, complete diet and medical histories, and whole blood, plasma, or serum taurine concentrations were obtained. Baseline and follow-up echocardiographic data were compared. Associations were evaluated between specific diets and taurine deficiency or congestive heart failure. The prevalence of low whole blood taurine concentrations in the healthy golden retrievers was calculated.
resultsTwenty-three of 24 dogs diagnosed with taurine deficiency and dilated cardiomyopathy were fed diets that were either grain-free, legume-rich, or a combination of these factors. None of these diets were feeding trial tested using Association of American Feed Control Officials (AAFCO) procedures. Twenty-three of 24 dogs had significant improvement in their echocardiographic parameters and normalization of taurine concentrations following diet change and taurine supplementation. Nine of 11 dogs diagnosed with congestive heart failure (CHF) had resolution of their congestion at follow-up with five no longer requiring diuretic therapy and four tolerating diuretic dose reduction by >50%.
conclusionsCertain diets and diet characteristics were associated with the development of taurine deficiency. Taurine deficiency and dilated cardiomyopathy in golden retrievers is likely multifactorial, including a combination of dietary, metabolic, and genetic factors.
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