ArticlePLoS genetics2018
Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- The role of methylation and structural variants in shaping the recombination landscape of barley.The Plant journal : for cell and molecular biology · 2026Article
- Allele variation at the Rdm3 locus conferring resistance to soybean southern stem canker.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Polymorphism can extensively reshape the genome-wide crossover landscape in Arabidopsis thaliana.Nature communications · 2026Article
- Overexpression of a novel CC-NBS-LRR gene NtRPP13 confers enhanced resistance to Ralstonia solanacearum in tobacco.Plant cell reports · 2025Article
- Mismatch repair disturbs meiotic crossover control in S. cerevisiae.Nucleic acids research · 2025Article
- COmapper: high-resolution mapping of meiotic crossovers by long-read sequencing in Arabidopsis.The New phytologist · 2025Article
- Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis.Genome biology · 2024Article
- The chromatin determinants and Ph1 gene effect at wheat sites with contrasting recombination frequency.Journal of advanced research · 2023Article
- Zinc homeostasis in Schizosaccharomyces pombe.Archives of microbiology · 2023Review
- The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids.Nature communications · 2023Article
- Evolution and molecular bases of reproductive isolation.Current opinion in genetics & development · 2022Review
- The megabase-scale crossover landscape is largely independent of sequence divergence.Nature communications · 2022Article
- Fast and Precise: How to Measure Meiotic Crossovers inMolecules and cells · 2022Review
- The N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B.The Plant cell · 2022Article
- Sexual dimorphism and the effect of wild introgressions on recombination in cassava (Manihot esculenta Crantz) breeding germplasm.G3 (Bethesda, Md.) · 2022Article
- Evolution of Recombination Landscapes in Diverging Populations of Bread Wheat.Genome biology and evolution · 2021Article
- MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis.The EMBO journal · 2020Article
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- Variation in Recombination Rate Is Shaped by Domestication and Environmental Conditions in Barley.Molecular biology and evolution · 2019Article
- Insights Into the Role of Ubiquitination in Meiosis: Fertility, Adaptation and Plant Breeding.The arabidopsis book · 2018Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
During meiosis, chromosomes undergo DNA double-strand breaks (DSBs), which can be repaired using a homologous chromosome to produce crossovers. Meiotic recombination frequency is variable along chromosomes and tends to concentrate in narrow hotspots. We mapped crossover hotspots located in the Arabidopsis thaliana RAC1 and RPP13 disease resistance genes, using varying haplotypic combinations. We observed a negative non-linear relationship between interhomolog divergence and crossover frequency within the hotspots, consistent with polymorphism locally suppressing crossover repair of DSBs. The fancm, recq4a recq4b, figl1 and msh2 mutants, or lines with increased HEI10 dosage, are known to show increased crossovers throughout the genome. Surprisingly, RAC1 crossovers were either unchanged or decreased in these genetic backgrounds, showing that chromosome location and local chromatin environment are important for regulation of crossover activity. We employed deep sequencing of crossovers to examine recombination topology within RAC1, in wild type, fancm, recq4a recq4b and fancm recq4a recq4b backgrounds. The RAC1 recombination landscape was broadly conserved in the anti-crossover mutants and showed a negative relationship with interhomolog divergence. However, crossovers at the RAC1 5'-end were relatively suppressed in recq4a recq4b backgrounds, further indicating that local context may influence recombination outcomes. Our results demonstrate the importance of interhomolog divergence in shaping recombination within plant disease resistance genes and crossover hotspots.
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