ArticleeLife2018
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State.Aging cell · 2026Article
- MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review).International journal of molecular medicine · 2026Review
- MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer's disease.Frontiers in immunology · 2026Article
- Tumor-derived small extracellular vesicles loaded with functionally active miR-34a mimic can modify the anti-tumor response in 4T1 breast cancer animal model.Cancer cell international · 2025Article
- Overexpression of the Dicer family genes influences lifespan and stress resistance in a tissue-, sex-, and stressor-specific manner in Drosophila melanogaster.Biogerontology · 2025Article
- The IL-23R and Its Genetic Variants: A Hitherto Unforeseen Bridge Between the Immune System and Cancer Development.Cancers · 2024Review
- MicroRNA signatures in the pathogenesis and therapy of inflammatory bowel disease.Clinical and experimental medicine · 2024Review
- MicroRNA-34 and gastrointestinal cancers: a player with big functions.Cancer cell international · 2024Review
- How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells.World journal of stem cells · 2023Review
- Role of microRNAs in the crosstalk between the gut microbiota and intestinal immune system.Bioscience of microbiota, food and health · 2023Review
- Dectin-1 signaling coordinates innate and adaptive immunity for potent host defense against viral infection.Frontiers in immunology · 2023Article
- The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity.Frontiers in immunology · 2023Review
- Gut Microbiota-MicroRNA Interactions in Intestinal Homeostasis and Cancer Development.Microorganisms · 2022Review
- Review
- A Novel Immune-Related Gene Signature to Identify the Tumor Microenvironment and Prognose Disease Among Patients With Oral Squamous Cell Carcinoma Patients Using ssGSEA: A Bioinformatics and Biological Validation Study.Frontiers in immunology · 2022Article
- Identification of the Crucial Role of CCL22 inFrontiers in genetics · 2022Article
- Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.Nature communications · 2021Article
- MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic.Frontiers in cell and developmental biology · 2021Review
- miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 2 countries.
Lihua WangKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Ergang WangCenter for Genomics and Computational Biology, Duke University, Durham, United States.ORCID 0000-0003-2550-3686
Yi WangCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Robert MinesCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Kun XiangCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Zhiguo SunCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Gaiting ZhouDepartment of Biomedical Engineering, Duke University, Durham, United States.
Kai-Yuan ChenCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Nikolai RakhilinCenter for Genomics and Computational Biology, Duke University, Durham, United States.
Shanshan ChaoKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Gaoqi YeKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhenzhen WuKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Huiwen YanKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Hong ShenAffiliated Hospital of Nanjing University of TCM, Nanjing, China.
Jeffrey EverittDepartment of Pathology, Animal Pathology Core, Duke University, Durham, United States.
Pengcheng BuKey Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-3208-0354
Xiling ShenCenter for Genomics and Computational Biology, Duke University, Durham, United States.ORCID 0000-0002-4978-3531
Duke University · USChinese Academy of Sciences · CNNanjing Traditional Chinese Medicine Hospital · CN
Funding
Robust Control of the Stem Cell NicheR35GM122465 · NIGMS · TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION · PI Xiling Shen · 2017 to 2026
$5.6MAn organotypic model recapitulating colon cancer microenvironment and metastasisU01CA214300 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, SHEN, XILING · 2017 to 2021
$3.1MEpigenomic Reprogramming in Patient Derived Models of Colorectal CancerU01CA217514 · NCI · DUKE UNIVERSITY · PI HSU, SHIAOWEN DAVID · 2018 to 2022
$3.1MRobustness of the Intestinal Stem Cell NicheR01GM114254 · NIGMS · DUKE UNIVERSITY · PI SHEN, XILING · 2015 to 2017
$918kMetabolic Reprogramming of Colon Cancer Liver MetastasisR21CA201963 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W., SHEN, XILING · 2016 to 2017
$380kNCI NIH HHS R21 CA201963NCI NIH HHS U01 CA214300NCI NIH HHS U01CA214300NCI NIH HHS U01 CA217514NCI NIH HHS U01CA217514NIGMS NIH HHS R01 GM114254NIGMS NIH HHS R01GM114254NIGMS NIH HHS R35 GM122465NIGMS NIH HHS R35GM122465NIH HHS R21CA201963
Abstract
Inflammation often induces regeneration to repair the tissue damage. However, chronic inflammation can transform temporary hyperplasia into a fertile ground for tumorigenesis. Here, we demonstrate that the microRNA
Indexed as
Gene Expression ProfilingAnimalsCells, CulturedCell Transformation, NeoplasticCitrobacter rodentiumColonEnterobacteriaceae InfectionsInflammationMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsNeoplastic Stem CellsReceptors, InterleukinTh17 CellsMicroRNAsMIRN34a microRNA, mouseReceptors, Interleukincancer biologyCitrobacter rodentiumcolon cancerinflammationmousestem cellTh17
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.