Evidence map›Paper›PMID 30543175›Full record

ArticleCurrent HIV research2018

HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.

Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Greer Waldrop, Uma Shanmugasundaram, Pannerselvam Nandagopal, Sunil Suhas Solomon, Amrose Pradeep, Shanmugam Saravanan, Kailapuri Gangatharan Murugavel

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Article in Current HIV research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Chinnambedu Ravichandran SwathirajanY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Ramachandran VigneshY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Greer WaldropUniversity of Maryland School of Medicine, College Park, MD 20742, United States.
Uma ShanmugasundaramEmory University, 201 Dowman Dr, Atlanta, GA 30322, United States.
Pannerselvam NandagopalY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Sunil Suhas SolomonY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Amrose PradeepY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Shanmugam SaravananY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Kailapuri Gangatharan MurugavelY. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.
Voluntary Health Services Hospital · INYR Gaitonde Centre for AIDS Research and Education · INEmory University · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations.

objectiveThis study evaluates cytokine expression and T-cells activation in relation to disease non-progression in LTNP.

methodsHIV-1 Subtype C infected LTNP (n=20) and progressors (n=15) were enrolled and flowcytometry assays were performed to study HIV-specific CD8 T-cells expressing IL-2, IFN-γ, TNF-α and MIP-1β against gag and env peptides. CD4+ T-cell activation was evaluated by surface expression of HLADR and CD38.

resultsProportions of cytokines studied did not differ significantly between LTNP and progressors, while contrasting correlations with disease progression markers were observed in LTNP. CD4+ T-cell activation rates were significantly lower in LTNP compared to progressors which indicate the potential role of T-cell activation rates in disease non-progression in LTNP.

conclusionLTNP and progressors showed similar CD8+ T-cell responses, but final conclusions can be drawn only by comparing multiple immune factors in larger LTNP cohort with HIV-1 infected individuals at various levels of disease progression. A possible role of HIV-1 subtype variation and ethnic differences in addition to host-genetic and viral factors cannot be ruled out.

Indexed as

HIV Long-Term SurvivorsLymphocyte ActivationADP-ribosyl Cyclase 1AdultCD8-Positive T-LymphocytesCross-Sectional StudiesCytokinesenv Gene Products, Human Immunodeficiency VirusFemaleFlow Cytometrygag Gene Products, Human Immunodeficiency VirusGenotypeHIV-1HIV InfectionsHLA-DR AntigensHumansADP-ribosyl Cyclase 1CD38 protein, humanCytokinesenv Gene Products, Human Immunodeficiency Virusgag Gene Products, Human Immunodeficiency VirusHLA-DR AntigensMembrane Glycoproteinsantiviral cytokine response in HIV LTNP.CD38HIV LTNPHIV non-progressionHLADRT-cell activation in HIV LTNP

Identifiers

PMID30543175
PMCPMC6416489
OpenAlexW2905118292

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.