ArticleCurrent Alzheimer research2019
The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia.
Article in Current Alzheimer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Chronic pain and risk of cognitive impairment: a meta-analysis of longitudinal cohort studies.Translational psychiatry · 2026Pooled it
- The Potential Contribution of Chronic Pain and Common Chronic Pain Conditions to Subsequent Cognitive Decline, New Onset Cognitive Impairment, and Incident Dementia: A Systematic Review and Conceptual Model for Future Research.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Longitudinal associations of pain and cognitive decline in community-dwelling older adults.Psychology and aging · 2022Trial
- Senior WISE intervention: Gender differences in bodily pain and trait anxiety.Archives of psychiatric nursing · 2021Trial
- Associations between pain and cognitive impairment in older adults: findings from the birjand longitudinal aging study.Aging clinical and experimental research · 2026Article
- Pain in Alzheimer's Disease: Disrupted Multilevel Integration of Nociception, Affective Processing and Clinical Expression Across Clinical and Preclinical Evidence.Life (Basel, Switzerland) · 2026Review
- Targeting Pain and Depression in Alzheimer's Disease: Translational Insights and Emerging Treatments.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Chronic Back Pain Increases Alzheimer's Disease Risk Independent of Gross Brain Structural Alterations: Genetic Evidence from Two Populations.Journal of pain research · 2026Article
- The association between preoperative chronic pain and postoperative delirium in elderly patients undergoing elective orthopedic surgery.Frontiers in medicine · 2026Article
- Mechanisms and Characteristics of Chronic Pain in Alzheimer's Disease: A Narrative Review.Current medicinal chemistry · 2026Review
- Multi-regional transcriptomic analysis reveals early nociceptive and neuroinflammatory alterations in APP/PS1 mice.Frontiers in immunology · 2026Article
- High-impact pain predicts subjective cognitive decline and interacts with APOE4 genotype in the development of objective cognitive impairment.The journal of pain · 2025Article
- Longitudinal online weekly reports of non-cognitive symptoms and events can differentiate incident mild cognitive impairment from stable cognitively healthy older adults.Journal of Alzheimer's disease : JAD · 2025Article
- High-impact chronic pain and cognitive decline among Mexicans aged 60 and older from 2012 to 2018.The journal of pain · 2025Article
- The Impact of Chronic Pain on Cognitive Function.Brain sciences · 2025Review
- History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.Journal of the International Neuropsychological Society : JINS · 2025Article
- Joint Pain and Leisure-Time Physical Activity: Cross-Sectional Findings From the Cardiovascular Health Study.Health science reports · 2025Article
- Mechanisms of comorbidity between Alzheimer's disease and pain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.Journal of biochemical and molecular toxicology · 2025Review
- An Exploratory Analysis of Contributors to Cognitive Functioning Among Sexual and Gender Minority Individuals Who Had COVID-19.Journal of homosexuality · 2025Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown.
objectiveWe aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults.
methodsParticipants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders.
resultsAmong participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant.
conclusionAs a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.