ArticleLa Radiologia medica2019
A rat model of acute kidney injury through systemic hypoperfusion evaluated by micro-US, color and PW-Doppler.
Article in La Radiologia medica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Imaging Assessment of Complex Renal Cysts: Comparative Value of Superb Microvascular Imaging and Contrast-Enhanced Ultrasound.Journal of personalized medicine · 2026Article
- Total flavonoids ofFrontiers in pharmacology · 2026Article
- Comparison of Hyperspectral Imaging and Microvascular Doppler for Perfusion Monitoring of Free Flaps in an In Vivo Rodent Model.Journal of clinical medicine · 2022Article
- Renal Doppler Ultrasound in the Evaluation of Renal Function in Patients with Sepsis.Applied bionics and biomechanics · 2022Article
- Gastrointestinal neuroendocrine neoplasms (GI-NENs): hot topics in morphological, functional, and prognostic imaging.La Radiologia medica · 2021Review
- In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury.International journal of molecular sciences · 2021Article
- Review
- Ultrasound and Photoacoustic Imaging of the Kidney: Basic Concepts and Protocols.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Percutaneous needle biopsy of retroperitoneal lesions: technical developments.Acta bio-medica : Atenei Parmensis · 2019Review
- Advances in diagnostic and interventional radiology.Acta bio-medica : Atenei Parmensis · 2019Article
- Internal hernias: a difficult diagnostic challenge. Review of CT signs and clinical findings.Acta bio-medica : Atenei Parmensis · 2019Review
- Magnetic resonance enterography (MRE) and ultrasonography (US) in the study of the small bowel in Crohn's disease: state of the art and review of the literature.Acta bio-medica : Atenei Parmensis · 2019Review
- Relationship between diagnostic imaging features and prognostic outcomes in gastrointestinal stromal tumors (GIST).Acta bio-medica : Atenei Parmensis · 2019Review
- Diagnostic value/performance of radiological liver imaging during chemoterapy for gastrointestinal malignancy: a critical review.Acta bio-medica : Atenei Parmensis · 2019Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo create an animal model of acute renal ischemia induced by systemic hypoperfusion, controllable and reproducible to study, in real time, hemorrhagic shock changes with micro-imaging. ANIMALS AND
methodsHemorrhagic shock was induced in rats activating a syringe pump setup to remove 1 mL/min of blood, through the femoral artery catheter. The withdrawal was continued until the mean arterial pressure (MAP) dropped to 25-30 mmHg. For the next 60 min, the MAP was maintained at a constant pressure value, by automatic pump infusion and withdrawal. Micro-ultrasound imaging was performed using the Vevo 2100 system with the MS250 transducer (13-24 MHz). Renal size, morphology and echogenicity were evaluated in B-mode. Renal blood flow was evaluated using color and PW-Doppler.
resultsAfter 1 h of ischemia, B-mode images documented slight changes in kidney echogenicity. Color and PW-Doppler analysis showed a reduction in renal blood flow in kidneys during the hypoperfusion with a progressive and significant change from baseline values of resistive index (RI). At the histological evaluation, 60 min of hypoperfusion resulted in ischemic changes in the kidneys.
conclusionsThe results of this experimental study encourage the use of the described model to study acute renal ischemia trough severe hypoperfusion. The histological data confirmed that the model was able to produce injury in renal parenchyma. It can be used to assess acute ischemic damage not only in the kidney but also in other organs by using all available dedicated small animals imaging techniques.
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