ArticlePlant molecular biology2019
Post-translational and transcriptional regulation of phenylpropanoid biosynthesis pathway by Kelch repeat F-box protein SAGL1.
Article in Plant molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
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- Post-transcriptional and post-translational regulation of anthocyanin biosynthesis in sweetpotato by Ib-miR2111 and IbKFB: Implications for health promotion.Journal of advanced research · 2025Article
- LRM3 positively regulates stem lodging resistance by degradating MYB6 transcriptional repressor in soybean.Plant biotechnology journal · 2025Article
- Time-resolved oxidative signal convergence across the algae-embryophyte divide.Nature communications · 2025Article
- The Role of E3 Ubiquitin Ligase GeneInternational journal of molecular sciences · 2025Review
- MetMiner: A user-friendly pipeline for large-scale plant metabolomics data analysis.Journal of integrative plant biology · 2024Article
- High-quality genome of a modern soybean cultivar and resequencing of 547 accessions provide insights into the role of structural variation.Nature genetics · 2024Article
- New insights into the evolution and local adaptation of the genusHorticulture research · 2024Article
- Transcriptomics and metabolomics reveal the underlying mechanism of drought treatment on anthocyanin accumulation in postharvest blood orange fruit.BMC plant biology · 2024Article
- Deciphering the intricate hierarchical gene regulatory network: unraveling multi-level regulation and modifications driving secondary cell wall formation.Horticulture research · 2024Article
- Telomere-to-telomere genome assembly of melon (Horticulture research · 2023Article
- Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2023Article
- Enhanced Resistance toInternational journal of molecular sciences · 2022Article
- The ease and complexity of identifying and using specialized metabolites for crop engineering.Emerging topics in life sciences · 2022Review
- Transcriptome-based analysis of key pathways relating to yield formation stage of foxtail millet under different drought stress conditions.Frontiers in plant science · 2022Article
- Article
- Association of gene expression with syringyl to guaiacyl ratio in sugarcane lignin.Plant molecular biology · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
key messageA Kelch repeat F-box containing protein, SMALL AND GLOSSY LEAVES1 (SAGL1) regulates phenylpropanoid biosynthesis as a post-translational regulator for PAL1 (phenylalanine ammonia-lyase) and an indirect transcriptional regulator for ANTHOCYANIDIN SYNTHASE. Phenylpropanoid biosynthesis in plants produces diverse aromatic metabolites with important biological functions. Phenylalanine ammonia-lyase (PAL) catalyzes the first step in phenylpropanoid biosynthesis by converting L-phenylalanine to trans-cinnamic acid. Here, we report that SMALL AND GLOSSY LEAVES1 (SAGL1), a Kelch repeat F-box protein, interacts with PAL1 protein for proteasome-mediated degradation to regulate phenylpropanoid biosynthesis in Arabidopsis. Mutations in SAGL1 caused high accumulation of anthocyanins and lignin derived from the phenylpropanoid biosynthesis pathway. We found that PAL enzyme activity increased in SAGL1-defective mutants, sagl1, but decreased in SAGL1-overexpressing Arabidopsis (SAGL1OE) without changes in the transcript levels of PAL genes, suggesting protein-level regulation by SAGL1. Indeed, the levels of PAL1-GFP fusion protein were reduced when both SAGL1 and PAL1-GFP were transiently co-expressed in leaves of Nicotiana benthamiana. In addition, bimolecular fluorescence complementation analysis suggested an interaction between SAGL1 and PAL1. We also found that the transcript levels of ANTHOCYANIDIN SYNTHASE (ANS) increased in the sagl1 mutants but decreased in SAGL1OE. Our results suggest that SAGL1 regulates phenylpropanoid biosynthesis post-translationally at PAL1 and transcriptionally at ANS.
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