ArticleEuropean radiology2019
Intrauterine fetal MR versus postmortem MR imaging after therapeutic termination of pregnancy: evaluation of the concordance in the detection of brain abnormalities at early gestational stage.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 21 citations in OpenAlex.
- Laminar pattern disruption in fetal incipient polymicrogyria: insights from post-mortem magnetic resonance imaging and neuropathological correlation.Pediatric radiology · 2026Article
- 7.0 Tesla MRI in fetal autopsy: a preliminary exploration of integrating image optimization with clinical practice in a multidisciplinary workflow.Quantitative imaging in medicine and surgery · 2026Article
- Post-mortem perinatal imaging: what is the evidence?The British journal of radiology · 2023Review
- The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging.Heliyon · 2023Article
- Review
- Fetal thick corpus callosum: new insights from neuroimaging and neuropathology in two cases and literature review.Neuroradiology · 2021Review
- Current state of perinatal postmortem magnetic resonance imaging: European Society of Paediatric Radiology questionnaire-based survey and recommendations.Pediatric radiology · 2021Article
- Brain fetal neuroradiology: a beginner's guide.Translational pediatrics · 2021Review
- Visualisation of fetal meconium on post-mortem magnetic resonance imaging scans: a retrospective observational study.Acta radiologica open · 2020Article
- Diagnostic assessment of foetal brain malformations with intra-uterine MRI versus perinatal post-mortem MRI.Neuroradiology · 2019Article
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11 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeFetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early gestational age (GA). MATERIAL AND
methodsWe retrospectively collected 53 fetuses who had undergone iuMRI and pmMRI for suspected brain anomalies. Two pediatric neuroradiologists reviewed iuMRI and pmMRI examinations separately and then together. We used Cohen's K to assess the agreement between pmMRI and iuMRI. Using the combined evaluation iuMRI+pMRI as the reference standard, we calculated the "correctness ratio." We used Somers' D to assess the cograduation between postmortem image quality and time elapsed after fetus expulsion.
resultsOur data showed high agreement between iuMRI and pmMRI considering all the categories together, for both observers (K1 0.84; K2 0.86). The correctness ratio of iuMRI and pmMRI was 79% and 45% respectively. The major disagreements between iuMRI and pmMRI were related to postmortem changes as the collapse of liquoral structures and distorting phenomena. We also found a significant cograduation between the time elapsed from expulsion and pmMRI contrast resolution and distortive phenomena (both p < 0.001).
conclusionsOur study demonstrates an overall high concordance between iuMRI and pmMRI in detecting fetal brain abnormalities at early GA. Nevertheless, for the correct interpretation of pmMRI, the revision of fetal examination seems to be crucial, in particular when time elapsed from expulsion is longer than 24 h. KEY POINTS: • IuMRI and pmMRI showed overall high concordance in detecting fetal brain abnormalities at early GA. • PmMRI corroborated the antemortem diagnosis and it could be a valid alternative to conventional brain autopsy, only when the latter cannot be performed. • Some caution should be taken in interpreting pmMR images when performed after 24 h from fetal death.
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