Observational studyKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019
Cartilage repair surgery prevents progression of knee degeneration.
Observational study in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- [Guideline for the treatment of patellofemoral cartilage defects/arthrosis].Orthopadie (Heidelberg, Germany) · 2025Guideline
- Pooled it
- Mid-Term Clinical Outcomes of Pullout Repair Combined with Osteochondral Autograft Transplantation for Medial Meniscus Posterior Root Tears with Focal Cartilage Defects: A Treatment-Stratified Cohort Study.Bioengineering (Basel, Switzerland) · 2026Article
- Preoperative knee cartilage degeneration in the patellofemoral joint results in worse clinical outcome scores 2 years after inverted V-shaped high tibial osteotomy.Journal of experimental orthopaedics · 2026Article
- A non-interventional study to evaluate the safety and effectiveness of a biphasic, chondrocyte-containing biomaterial (NOVOCART® 3D) in the treatment of localized full-thickness cartilage defects or osteochondral lesions of the knee joint (NISANIK).Journal of experimental orthopaedics · 2025Article
- Secondary matrix-associated autologous chondrocyte implantation after failed cartilage repair shows superior results when combined with autologous bone grafting: Findings from the German Cartilage Registry (KnorpelRegister DGOU).Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- The Condition of the Meniscus and Cartilage of the Injured Knee on Preoperative Magnetic Resonance Imaging Is a Prognostic Factor Affecting Postoperative Outcomes Following Knee Cartilage Restoration Surgery.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Clinical Outcomes and Long-term Survivorship After Osteochondral Autologous Transfer Combined With Valgus High Tibial Osteotomy: An Analysis After 19 Years With 56 Patients.The American journal of sports medicine · 2024Article
- All-Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for a Trochlear Defect.Arthroscopy techniques · 2024Article
- Correlation between the quality of cartilage repair tissue and patellofemoral osteoarthritis after matrix-induced autologous chondrocyte implantation at three-year follow-up: a cross-sectional study.International orthopaedics · 2023Article
- Engineering Inflammation-Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering.Advanced healthcare materials · 2023Article
- Low postoperative complication rate with high survival rate and good clinical outcome 9 years after autologous chondrocyte transplantation of the knee joint.Archives of orthopaedic and trauma surgery · 2023Article
- Article
- Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short-term results in comparison with isolated cartilage repair in ligament intact joints.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Articular cartilage delamination at eight years following cellular-based repair procedures: a case reports.Journal of experimental orthopaedics · 2022Article
- [Autologous chondrocyte transplantation with bone augmentation for the treatment of osteochodral defects of the knee : Treatment of osteochondral defects of the femoral condyles using autologous cancellous bone from the iliac crest combined with matrix-guided autologous chondrocyte transplantation].Operative Orthopadie und Traumatologie · 2022Review
- Patellofemoral cartilage defects are acceptable in patients undergoing high tibial osteotomy for medial osteoarthritis of the knee.BMC musculoskeletal disorders · 2022Article
- Patellar instability MRI measurements are associated with knee joint degeneration after reconstruction of the medial patellofemoral ligament.Skeletal radiology · 2022Article
- Safety and Efficacy of Matrix-Associated Autologous Chondrocyte Implantation With Spheroids for Patellofemoral or Tibiofemoral Defects: A 5-Year Follow-up of a Phase 2, Dose-Confirmation Trial.Orthopaedic journal of sports medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
purposeTo investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6 years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI).
methodsA total of 32 individuals received baseline and follow-up MRI. In n = 16 patients with cartilage repair [osteochondral autograft transfer system (OATS), n = 12; spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI), n = 4] MRI was performed preoperatively and after 5.7 ± 2.3 year follow-up. Baseline MRIs of non-operated subjects from the OAI were screened for initially identical cartilage defects (n = 16). Morphological knee abnormalities were assessed using WORMS, AMADEUS and MOCART scores. A sagittal 2D MSME sequence was implemented for quantitative cartilage T2 relaxation time measurements in all (0, 2, 4, 6 and 8-years) follow-ups from the OAI and in the postoperative MRI protocol.
resultsFor both groups, focal osteochondral defects were located at the femoral condyle in 8/16 cases (5 medial, 3 lateral) and at the patella in 8/16 cases. At baseline, the mean cartilage defect size ± SD was 1.4 ± 1.3 cm
conclusionsPatients with cartilage repair showed less progression of degenerative MRI changes at 6-year follow-up than a control cohort from the OAI with initially identical osteochondral defects. Patients with focal cartilage defects may profit from cartilage repair surgery since it may prevent progression of early osteoarthritis at the knee joint. LEVEL OF EVIDENCE: Prognostic study, Level II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.