Evidence map›Paper›PMID 30542674›Full record

ArticleJournal of stem cell and transplantation biology2017

It's Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia.

Haidong Huang, Kevin Yu, Alireza Mohammadi, Efstathios Karanthanasis, Andrew Godley, Jennifer S Yu

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of stem cell and transplantation biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06271421 (Application of Nanoparticles for Cyclic Hyperthermia In Adjuvant Therapy of gLioblastoma Multiforme), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06271421 narecruitingnot on this mapstarted 2024, after this paper: background citation

Application of Nanoparticles for Cyclic Hyperthermia In Adjuvant Therapy of gLioblastoma Multiforme (ANCHIALE)

TypeinterventionalSponsorPoznan University of Medical SciencesRan2024 to 2027Enrolled100ConditionsGlioblastoma MultiformeArmsNanoTherm therapy, Glioma Resection, radiotherapy according to Stupp protocol, chemotherapy according to Stupp protocol
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Novel ablation methods for treatment of gliomas.Journal of neuroscience methods · 2020
    Review
  10. New physical approaches to treat cancer stem cells: a review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Haidong HuangDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE30, Cleveland, OH 44195, USA.
Kevin YuDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE30, Cleveland, OH 44195, USA.
Alireza MohammadiDepartment of Neurosurgery, Rose Ella Burckhardt Brain tumor and Neuro-oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, CA51, Cleveland, OH 44195, USA.
Efstathios KaranthanasisDepartment of Biomedical Engineering, Case Western Reserve University, 1900 Euclid Avenue, Cleveland, OH 44106, USA.
Andrew GodleyDepartment of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, CA50, OH 44195, USA.
Jennifer S YuDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE30, Cleveland, OH 44195, USA.
Cleveland Clinic Lerner College of Medicine · US

Funding

Selective Targeting of Glioma Stem Cells Through Sema3C/PlexinD1R01NS092641 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI YU, JENNIFER S · 2016 to 2020
$1.7M
Hypoxia Regulates Notch Turnover in Glioma Stem Cells Through VasorinR01NS094199 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI YU, JENNIFER S · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS092641NINDS NIH HHS R01 NS094199
6 · The paper itself

Abstract

Cancer stem-like cells (CSCs) are a subset of cancer cells that are resistant to conventional radiotherapy and chemotherapy. As such, CSCs have been recognized as playing a large role in tumor initiation and recurrence. Although hyperthermia is broadly used in cancer treatment either alone or in combination with radio- or chemo-therapy, its potential to target CSCs is not well understood. In this review, we discuss different types of hyperthermia and potential mechanisms of action in cancer treatment, particularly in regards to killing CSCs.

Indexed as

AblationCancer stem-like cellsChemotherapyCytotoxic treatmentHyperthermiaLITTNanoparticleRadiation

Identifiers

PMID30542674
PMCPMC6287629
OpenAlexW2783872428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.