Evidence map›Paper›PMID 30542582›Full record

ArticleChemical science2018

Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2.

Xuan-Yu Meng, Seung-Gu Kang, Ruhong Zhou

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xuan-Yu MengState Key Laboratory of Radiation Medicine and Protection , School for Radiological and Interdisciplinary Sciences (RAD-X) , Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , China.
Seung-Gu KangIBM Thomas J. Watson Research Center , Yorktown Heights , NY 10598 , USA . Email: ruhongz@us.ibm.com.
Ruhong ZhouState Key Laboratory of Radiation Medicine and Protection , School for Radiological and Interdisciplinary Sciences (RAD-X) , Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions , Soochow University , Suzhou 215123 , China.ORCID 0000-0001-8624-5591
Soochow University · CNIBM Research - Thomas J. Watson Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphoinositides are essential signaling lipids that play a critical role in regulating ion channels, and their dysregulation often results in fatal diseases including cardiac arrhythmia and paralysis. Despite decades of intensive research, the underlying molecular mechanism of lipid agonism and specificity remains largely unknown. Here, we present a systematic study of the binding mechanism and specificity of a native agonist, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Identifiers

PMID30542582
PMCPMC6247517
OpenAlexW2891089313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.